| 双核微核的形成机制、结局及影响因素的研究进展 |
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| 引用本文： | 林超,;张光辉,;何金玉,;夏昭林. 双核微核的形成机制、结局及影响因素的研究进展[J]. 职业卫生与应急救援, 2014, 32(5): 268-271 |
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| 作者姓名： | 林超, 张光辉, 何金玉, 夏昭林 |
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| 作者单位： | 1. 芜湖市疾病预防控制中心, 安徽芜湖 241000; |
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| 基金项目： | 国家自然基金项目（NSFC81474929,J1210041）; 科技部973项目2011CB503801 |
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| 摘 要： | 外周血微核试验是检测染色体损伤和快速筛选环境化学物致突变的常用遗传毒理学方法,其中胞质分裂阻滞微核试验(cytokinesis-block micronucleus assay,CBMN)是应用最广泛的检测外周血微核率的方法,后者已经作为生物标志广泛应用到染色体损伤和基因稳定性的研究中。为更好地促进CB微核在职业和环境毒物接触人群健康监护中的研究和应用,对CB微核的形成机制、结局、影响因素和优缺点及其研究进展做了综述。
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| 关 键 词： | 双核微核 生物标志 遗传损伤 |
| 收稿时间： | 2014-05-23 |
Review of the origin,fate,and influencing factors of cytokinesis-block micronucleus |
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| Affiliation: | LIN Chao,ZHANG Guang-hui,HE Jin-yu,XIA Zhao-lin(1. Wuhu center for disease control and prevention, Wuhu,A nhui 241000, China; 2. School of public health, Fudan University, Shanghai 200032,China;3. School of public health,Xinxiang medical University,Xinxiang,Henan 453003, China) |
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| Abstract: | Measurement of micronuclei in peripheral blood is usually used to detect chromosome damage and mutagenic action of environmental chemicals in toxicology. The cytokinesis-block micronucleus（CBMN） assay is the most widely used method for measuring micronuclei in human lymphocytes,which has been considered as a useful biomarker to detect chromosome damage and gene stability. In this paper,the formation mechanism,endpoint,and the influencing factors of CBMN and the advantage and disadvantage of CBMN assay is reviewed to boost the use of cytokinesis-block micronucleus in protecting workers exposed to environmental chemicals. |
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| Keywords: | Cytokinesis-block micronucleus Biomarker Genetic damage |
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