男性冠心病患者血浆睾酮与超敏C反应蛋白、白介素-6及同型半胱氨酸的关系

目的观察男性冠心病患者血浆睾酮水平与血浆中超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、同型半胱氨酸(Hcy)水平的关系。方法将95例患者分为冠心病组(50例)与对照组(45例),分别检测两组睾酮、hs-CRP、IL-6、Hcy、总胆固醇(TC)、甘油三酯(TG)水平,并收集两组病例年龄、吸烟史、高血压史、体质指数等基本临床信息。结果冠心病组与对照组在年龄、高血压史、吸烟史、体质指数、血脂水平比较差异均无统计学意义(P0.05)。冠心病组与对照组相比,血浆睾酮显著低于对照组,hs-CRP、IL-6、Hcy显著上升(P0.05)。Pearson直线相关分析表明,冠心病组的血浆睾酮水平与hs-CRP(r=-0.760,P0.05)、IL-6(r=-0.625,P0.05)、Hcy(r=-0.529,P0.05)水平呈显著负相关。结论冠心病患者血浆睾酮水平降低,但Hcy及炎性反应水平升高;睾酮的水平与炎性反应水平和Hcy水平呈负相关。

Relationship between testosterone and high-sensitivity C-reactive protein,interleukin-6,homocysteine in male patients with coronary heart disease

Objective To investigate the relationship of testosterone and high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6) and homocysteine(Hcy) in old male patients with coronary heart disease(CHD).Methods 50 CHD patients and 45 control subjects were selected from nanfang hospital.Levels of hs-CRP,IL-6,Hcy,total cholesterol(TC),triglyceride(TG) and testosterone were determined.Basic clinical data including age,smoking,hypertension and body mass index(BMI) were evaluated.Results Compared with control subjects,hs-CRP,IL-6,homocysteine were elevated and testosterone was decreased(P<0.05) in CHD group.There was no significant difference in age,BMI,TC and TG between two groups.There was negative correlation between CRP,IL-6,homocysteine and testosterone.Conclusions Male patients with CHD have lower level of testosterone and decreased testosterone,which appears to be associated with greater inflammation reaction in vascular and higher level of homocysteine.