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| 苦碟子注射液对大鼠急性脑缺血-再灌注损伤的保护作用 | |
| 引用本文： | 陈春光,贾洪丽,吕首旭,徐长庆. 苦碟子注射液对大鼠急性脑缺血-再灌注损伤的保护作用[J]. 中国临床药理学杂志, 2012, 28(3): 196-199 |
| 作者姓名： | 陈春光 贾洪丽 吕首旭 徐长庆 |
| 作者单位： | 1. 黑龙江省医院急诊科,哈尔滨,150056 2. 哈尔滨医科大学病理生理教研室,哈尔滨,150086 3. 黑龙江省红十字医院神经内科,哈尔滨,150040 4. 哈尔滨医科大学,病理生理教研室,哈尔滨 150086;哈尔滨医科大学,黑龙江生物医药工程重点实验室,哈尔滨 150086 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 目的观察苦碟子注射液对脑缺血-再灌注损伤的保护作用并探讨其可能机制。方法用线栓法制作大鼠大脑中动脉栓塞模型(MCAO)。大鼠随机分成假手术组(sham)、脑缺血-再灌注损伤组(I/R)和苦碟子保护组(KD)。观察神经功能学评分,形态学观察(光镜和电镜),如脑梗塞面积(HE染色)及测定脑组织丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性。结果苦碟子注射液可降低缺血-再灌注损伤后的神经功能学评分、脑梗死面积、缺血脑组织丙二醛含量,减轻形态结构损伤,提高超氧化物歧化酶活性。结论苦碟子注射液对于脑缺血-再灌注损伤有一定的保护作用,其作用机制与清除氧自由基和抗脂质过氧化有关。 |
| 关 键 词： | 苦碟子注射液 脑缺血/再灌注损伤 丙二醛 超氧化物歧化酶 |
Protective effect of Kudiezi on acute cerebral ischemic reperfusion injury in rats |
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| CHEN Chun-guang , JIA Hong-li , LV Shou-xv , XU Chang-qing. Protective effect of Kudiezi on acute cerebral ischemic reperfusion injury in rats[J]. The Chinese Journal of Clinical Pharmacology, 2012, 28(3): 196-199 | |
| Authors: | CHEN Chun-guang JIA Hong-li LV Shou-xv XU Chang-qing |
| Affiliation: | 1.Department of Emergency,Heilongjiang Province Hospital,Harbin 150001,China;2.Department of Pathophysiology,Harbin Medical University,Harbin 150086,China;3.Department of Neurology,Red Cross Hospital of Heilongjiang Province,Harbin 150040,China;4.a.Department of Pathophysiology,b.Bio-pharmaceutical Key Laboratory of Heilongjiang Province,Harbin Medical University,Harbin 150086,China) |
| Abstract: | Objective To observe the protective effects of Kudiezi injection on acute cerebral ischemic reperfusion injury and explore the possible mechanisms.Methods The rat cerebral ischemia/reperfusion injury(I/R) model was established by middle cerebral artery occlusion(MCAO).The rats were randomly divided into three groups,sham group,I/R group and Kudiezi protection group(KD).Neurological deficit score,cerbral infarction size(TTC staining),HE staining and morphology(light microscope and electron microscope),the SOD activity and content of MDA were measured.Results The neurological deficit score,cerbral infarction size and content of MDA were decreased,while the activity of SOD was increased and ultrastructure were improved in Kudiezi injection group,compared with I/R group.Conclusion Kudiezi injection had protective effects on cerebral ischemia /reperfusion injury,which mechanism may be related with scavenging free radical and anti-lipid peroxidation. |
| Keywords: | Kudiezi injection cerebral ischemia/reperfusion injury malondialdehyde superoxide dismutase |
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