早期应用阿托伐他汀对不稳定型心绞痛患者高敏C-反应蛋白水平的影响

目的 通过研究早期应用阿托伐他汀对不稳定型心绞痛（UA）患者高敏C-反应蛋白（hs-CRP）的影响,探讨阿托伐他汀在UA治疗中的早期抗炎效应.方法 选择2010-07-2011-07在山东省青岛疗养院住院的UA患者50例,男28例,女22例,平均年龄（59.85±12.61）岁;选取同期本院查体中心正常健康者50例为对照组,男28例,女22例,平均年龄（59.23±12.13）岁.UA患者给予阿托伐他汀治疗（20 mg/d,共4周）,均在入院次日（用他汀类药物前）、治疗1周后、治疗2周后、治疗4周后清晨空腹采血,测定血清hs-CRP浓度及血脂水平.结果 UA患者用药前与正常对照组比较血脂及hs-CRP均升高,差异有统计学意义（P＜0.05）.UA患者在给予阿托伐他汀治疗1周、2周、4周后血清hs-CRP浓度及血脂水平与用药前相比差异有统计学意义（P＜0.05）,且治疗前后血脂变化与血清hs-CRP下降之间无相关关系（P＞0.05）.结论 早期应用阿托伐他汀可以使UA患者血清hs-CRP水平明显下降,推测早期应用他汀类可能有降低血浆炎性因子、减轻炎症反应状态,从而稳定斑块,对防止不稳定斑块的破裂起到有益的作用,此作用与其调脂作用无关,为临床UA患者早期应用他汀类治疗提供了一定依据.

Influence of early use of atorvastatin on hypersensitive C-reactive protein(hs-CRP)level in patients with unstable angina

Objective To observe the anti-inflammatory influence of early intervention with atorvastatin on serum hs-CRP level in patients with unstable angina.Methods 50 patients(28 males and 22 females,average age 59.85±12.61)with UA at Qingdao sanatorium Shandong province during July,2010 and July,2011 were selected,and another 50 healthy people from our physical examination center(28 males and 22 females,average age 59.23±12.13)were selected to be the control group.All patients were treated with atorvastatin(20 mg/d,4 weeks).The concentration of serum hs-CRP and the level of blood lipids were measured by blood collection with empty stomach respectively one day after admission(before the use of statins),one week,two weeks and four weeks after treatment.Results The level of blood lipids and serum hs-CRP of all patients before atorvastatin treatment were higher than those of the control group,and the difference was of statistic significance(P<0.05).After being treated with atorvastatin 20 mg/d,for one week,two weeks and four weeks,the concentration of serum hs-CRP and the level of blood lipids of all patients were statistically different from those before the treatment(P<0.05).The decrease of hs-CRP had no relationship with blood lipids changes before and after the treatment(P>0.05).Conclusion Early use of atorvastatin can clearly decrease the concentration of serum hs-CRP in patients with UA.So it is assumed that early use of statins can be helpful for reducing blood plasma inflammation factors so as to stabilize plaque.Thus it can provide information for early use of statins for patients with UA.