甘草酸二铵脂质复合物对大鼠非酒精性脂肪肝的治疗效果研究

目的:研究甘草酸二铵脂质复合物(甘平,DGLL)对大鼠非酒精性脂肪肝(NAFLD)的治疗作用。方法:以高脂饲料喂养方式建立大鼠非酒精性脂肪肝模型,证实造模成功后随机分为空白对照组、模型组、多烯磷脂酰胆碱组和甘平高中低(900、300、100mg/kg)剂量组。给药4周后,处死所有动物,检测血脂、氧化应激、肝功能、胰岛素相关等指标,并观察肝脏组织病理学变化。结果:甘平能显著降低NAFLD大鼠的转氨酶(ALT、AST)活力、丙二醛(MDA)含量、TNF-α水平、空腹血糖(FBG)、空腹胰岛素(FINS)水平和空腹胰岛素抵抗指数(HOMA-IR),升高超氧化物歧化酶(SOD)活力,改善NAFLD大鼠的总胆固醇(TC)、甘油三酯(TG)水平。结论:甘平可以用来治疗大鼠NAFLD,其机制可能与抗氧化作用及改善胰岛素抵抗有关。

Effects of diammonium glycyrrhizinate phosphatidylcholine complex treatment on rat nonalcoholic fatty liver disease

AIM: To observe the therapeutically effect of diammonium glycyrrhizinate phosphatidylcholine complex(DGLL) on the non alcoholic fatty liver disease(NAFLD).METHODS: NAFLD rat model was constructed by feeding rats with high fatty and cholesterol diet for 8 weeks.And NAFLD model was subdivided into 6 subgroups: control group,model group,polygene phosphatidylcholine capsules group and DGLL groups(100,300,900 mg/kg).At the end of 12 week,all rats were killed to detect the blood lipids,oxidative stress,liver function,insulin-related and the pathological changes.RESULTS: DGLL could significantly reduce the NAFLD rats aminotransferase(ALT,AST) activity,malondialdehyde(MDA) content,TNF-α level,fasting blood glucose(FBG),fasting insulin(FINS) level and fasting insulin resistance index(HOMA-IR).DGLL could also increase superoxide dismutase(SOD) activity and improve NAFLD rats total cholesterol(TC) and triglyceride(TG) levels.CONCLUSION: DGLL can be used to treat NAFLD,and the mechanism may be related to lowering blood lipids and improving liver function,anti-oxidation and insulin resistance.