118例甲亢患者骨密度及骨代谢指标的研究

目的：为探讨甲亢患者骨密度与骨代谢指标的改变。方法：本文测定了１１８例甲亢患者腰椎（Ｌ２～４）及股骨上端（Ｎｅｃｋ、Ｗａｒｄ三角、Ｔｒｏｃｈ）骨密度、血清骨钙素（ＢＧＰ）、甲状旁腺素中间片段（ＰＴＨ－ｍ）及尿脱氧吡啶啉（Ｄｐｄ）。结果：甲亢患者骨密度低于正常对照组，ｔ检验具显著差异（ｐ＜０．０１）、血清ＢＧＰ及Ｄｐｄ高于正常对照组，ｔ检验具显著差异（ｐ＜０．０１），与骨密度呈负相关ｒ＝－０．２１３５、－０．２０５０（ｐ＜０．０５）；而ＰＴＨ－ｍ低于正常对照组，与骨密度无相关性ｒ＝０．０８３０（ｐ＞０．０５）。结论：甲亢为高转换型骨质疏松，ＢＧＰ、Ｄｐｄ可作为骨形成及骨吸收的敏感指标

Changes of bone mineral density and bone metabolism in hyperthyroid patients

Purpose To investigate the changes of bone mineral density (BMD) and bone metaboism in patients with hyperthyroidism .Methods BMD of lumbar spines and femur neck,Ward's triangle and trochauter,serum bone Gla protein (BGP),PTH m and urine deoxypyridnoline (Dpd) were measured in 118 hyperthyroidism patients and 110 normal controls.Results BMDs were lower,serum BGP and urine Dpd concentration higher in hyperthyoid patients than in the controls ( p <0 01).Both BGP and Dpd negatively correlated with BMD(r values being -0.2135 and -0.2050,respectively, p <0 05).Serum PTH m reduced and not correlated with BMD.Conclusion High turnover type osteoporosis exists in hypethyroidism and BGP and Dpd appear to be sensitive indices reflecting bone formation and resorption.