| 视网膜色素上皮损伤后相邻感光细胞及脉络膜血管的病理变化 |
| |
| 引用本文： | 张陶然,胡运韬,李颖,吴建国,王艳玲,马志中. 视网膜色素上皮损伤后相邻感光细胞及脉络膜血管的病理变化[J]. 国际眼科杂志, 2009, 9(6): 1041-1045. DOI: 10.3969/j.issn.1672-5123.2009.06.009 |
| |
| 作者姓名： | 张陶然 胡运韬 李颖 吴建国 王艳玲 马志中 |
| |
| 作者单位： | 1. 首都医科大学附属北京友谊医院眼科,中国北京市,100050
2. 北京大学眼科中心,中国北京市,100083 |
| |
| 基金项目： | 中国国家重点基础研究发展规划资助项目("973"项目)，中国北京大学第三医院重点临床项目 |
| |
| 摘 要： | 目的:研究视网膜色素上皮(retinal pigment epithelium,RPE)损伤后相邻感光细胞和脉络膜血管的病理变化。方法:机械性刷除青紫蓝兔眼底髓线上方的RPE细胞,观察术后7,14,30d和90d清除区相邻感光细胞和脉络膜血管变化。结果:RPE细胞清除术后相邻的感光细胞发生退行性改变和死亡,脉络膜毛细血管萎缩。结论:RPE清除术可模拟萎缩型年龄相关性黄斑变性(age-related macular degeneration,AMD)及渗出型AMD剥膜以后的病理变化,为自体RPE移植挽救损伤的感光细胞的实验提供了良好的动物模型。
|
| 关 键 词： | 视网膜色素上皮 感光细胞 脉络膜毛细血管 黄斑变性 |
Histopathological changes of photoreceptors and choroids after retinal pigment epithelium debridements |
| |
| Tao-Ran Zhang,Yun-Tao Hu,Ying Li,Jian-Guo Wu,Yan-Ling Wang,Zhi-Zhong Ma. Histopathological changes of photoreceptors and choroids after retinal pigment epithelium debridements[J]. International Eye Science, 2009, 9(6): 1041-1045. DOI: 10.3969/j.issn.1672-5123.2009.06.009 |
| |
| Authors: | Tao-Ran Zhang Yun-Tao Hu Ying Li Jian-Guo Wu Yan-Ling Wang Zhi-Zhong Ma |
| |
| Affiliation: | Tao-Ran Zhang1,Yun-Tao Hu2,Ying Li2,Jian-Guo Wu2,Yan-Ling Wang1,Zhi-Zhong Ma21Department of Ophthalmology,Beijing Friendship Hospital Affiliated to Capital Medical University,Beijing 100050,China,2Eye Center,Peking University,Beijing 100083 |
| |
| Abstract: | AIM:To create a retinal pigment epithelium(RPE) debridement animal model and observe the histopatho-logical changes.·METHODS: A brasive debridement of RPE was per-formed with a metal cannula after superior retinal bleb detachments in rabbits. Animals were examined by fundus fluorescein angiography(FFA)and indocyanine green angiography(ICGA)in seriate 7 days,14 days,1 month and 3 months post-debridements. And tissue sections were evaluated using light microscope and transmission electron microscope at corresponding time points.·RESULTS: The debrided area was not completely resurfaced by surrounding elongated RPE cells;the choriocapillaries beneath the debrided area underwent degeneration;and the photoreceptors overlying the debrided area showed gradually degeneration and loss.·CONCLUSION: The type of abrasive debridement has been suggested as a model of therapy for macular degeneration as there is a high correlation between RPE dropout,choriocapillaries atrophy and loss of photorece-ptors function. |
| |
| Keywords: | retinal pigment epithelium photoreceptor cell choriocapillary macular degeneration |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
