广东省1990～2000年登革热流行病学分析

目的 明确广东省登革热流行因素。探讨预防控制对策。方法 调查分析1990-2000年登革热病例的分布特征和流行因素，测定登革Ⅰ型病毒地方分离株E/NS1基因片段核苷酸序列。结果 1990-2000年间，广东省共报告登革热病例9747例，死亡3例。年发病率在0/10万-9.75/10万之间，平均为1.27/10万。流行多呈爆发，疫情涉及13个市（占全省21个市的61.9%)。主要集中在广州，潮州，肇庆和佛山市，呈现高度集中而相对分散特点，敏月均有登革热病例报告，其中1-6月份为散发输入病例，7-12月份为流行期，男性：女性为1.04:1，所有年龄组均易感，四个型别的登革病毒均发生过流行，同一地区不同年份可流行不同型别病毒，同一年份不同地区也可流行不同型别病毒，广东省12株登革Ⅰ型病毒地方分离株E/NS1基因片段核苷酸序列，显示广东省登革Ⅰ型代表毒株可分为两个基因亚型。临床表现以典型登革热为主，广东省存在有利于登革热流行的自然因素和社会因素。结论 广东省登革热疫情同国外登革热流行程度相关联。流行呈输入性流行的特征，至今仍无证据表明已成为地方性疾病。

Analysis on the epidemiologic features of Dengue fever in Guangdong province, 1990-2000

Objective To determine the epidemiological characteristics and risk factors of Dengue fever in Guangdong province in 1990 2000, and to develop the strategy for its prevention and control. Methods Sequencial of the partial nucleotide fragments in E/NS1 gene juction was analysed. Results A total of 9 747 cases were reported with three deaths in Guangdong province, 1990 2000. The average incidence was 1.27 per 10 thousands (range: 0 9.75 per 10 thousands). Outbreaks were commonly seen, with 13 cities ( 61.9 %) involved, but most of the cases occurred in Guangzhou, Chaozhou, Zhaoqing and Foshan cities.Numbers of cases reported monthly were gathered with sporadic imported cases reported from January to June while the period of epidemics was from July to December. Sex ratio of patients was 1.04 , but all age group was susceptible. Four sero types of Dengue virus were found during these epidemics. The partial nucleotide fragments in E/NS1 gene junction of 12 isolated viruses were sequenced and 2 sub gene types were identified in Guangdong province. The clinical symptoms seemed typical. Social and natural factors were responsible for the epidemic of Dengue fever in the regions. Conclusion The epidemic of Dengue fever in Guangdong was closely related to the situations of neighboring countries, indicating the possibility of importation of virus from these countries. The epidemics usually started with imported cases. However, the endemic nature of the disease had not been identified yet.