| 人参皂甙Re对大鼠心肌缺血-再灌注损伤时心肌和血浆前列腺素E_2水平的影响 |
| |
| 引用本文： | 白长喜,方文龙.人参皂甙Re对大鼠心肌缺血-再灌注损伤时心肌和血浆前列腺素E_2水平的影响[J].延边医学院学报,1993(1). |
| |
| 作者姓名： | 白长喜 方文龙 |
| |
| 作者单位： | 延边医学院药理学教研室，延边医学院药理学教研室 |
| |
| 摘 要： | 在大鼠心肌缺血-再灌注损伤模型上,研究了人参皂甙Re(10mg/kg和20mg/kg)对心肌和血浆中前列腺素E_2(PGE_2)水平的影响,并与维拉帕米进行了比较。人参皂甙Re10mg/kg和20mg/kg及维拉帕米均可抑制大鼠心肌和血浆中PGE_2水平的升高,并且人参皂甙Re10mg/kg和20mg/kg的作用均优于维拉帕米,提示人参皂甙Re对大鼠心肌缺血-再灌注时在循环血中和心肌内PGE_2大量蓄积所致的心脏损害有显著的保护作用。
|
| 关 键 词： | 人参 皂甙类 灌注法 前列腺素 E 类 |
Effects of Ginsenoside Re on the Contents of PGE_2 in Rat Myocardium and Plasma During Myocardium Ischemia/Reperfusion Damage |
| |
| Bai Changxi Fang Wenlong.Effects of Ginsenoside Re on the Contents of PGE_2 in Rat Myocardium and Plasma During Myocardium Ischemia/Reperfusion Damage[J].Journal of Medical Science Yanbian University,1993(1). |
| |
| Authors: | Bai Changxi Fang Wenlong |
| |
| Abstract: | The contents of PGE_2 in myocardium and plasma are obviously increasing during rat myocardium ischemia/reperfusion damage. Large or small dose of ginsenoside Re (20mg/kg, 10mg/kg) and verapamil (0.2mg/kg) can reduce the contents of PGE_2 during rat myocardium ischemia/reperfusion, they also can abate the rat myocardium ischemia/reperfusion damage caused by PGE_2 in vitro. It suggests that ginsenoside Re on reducing the contsnts of PGE_2 in rat myocardium and plasma is better than verapamil. Those results further demonstrate that ginseosidc Re has the anti-lipid peroxidation effect and the prevention and cure effects during myocardium ischemia/reperfusion damage. |
| |
| Keywords: | ginseng saponine reperfusion prostaglandins E_2 |
| 本文献已被 CNKI 等数据库收录！ |
