肾移植术后的巨细胞病毒感染及其对急性排斥反应的影响

目的 探讨肾移植受者术后活动性巨细胞病毒（ＣＭＶ）感染的发生率、感染的原因以及ＣＭＶ感染对急性排斥反应的影响。方法 检测１８７例肾移植受者和供者术前血清抗－ＣＭＶ抗体；受者术后定期检测体内ＣＭＶ ＤＮＡ、对ＣＭＶ ＤＮＡ阳性的部分患者给予抗ＣＭＶ治疗，并比较各组排斥反应的发生率。结果 无论是供者还是受者，术前如血清抗－ＣＭＶ抗体阳性，受者术后发生活动性ＣＭＶ感染者明显增多，这些患者急性排斥反应的发

The cytomegalovirus infection in renal allograft recipients and its impact on acute rejection

Objectives To investigate the incidence and causes of cytomegalovirus (CMV) infection and the relationship between acute rejection and CMV infection in renal allogaft recipients. Methods 187 consecutive renal allograft recipients and their donors were subjected to the serum test for CMV antibody before transplantation. PCR was used to detect CMV DNA in peripheral blood leukocyte specimens of the recipients after operation. Part patients with positive CMV DNA were given to anti CMV treatment. Results CMV DNA was found in 43.3% of the recipients in the first month after transplantation. CMV DNA( ) was significantly more common in recipients who were CMV seropositive before transplantation. The kidney from a CMV seropositive donor had a high risk factor of developing CMV infection for a CMV seronegative recipient. CMV DNA( ) significantly enhanced the development of acute rejection at least during the first 3 months following transplantation. Ganciclovir therapy significantly reduced the number of acute rejection episodes with eliminating of CMV DNA in peripheral blood leukocytes. Conclusion It is important to prevent and treat CMV infection in renal allograft recipients.