| 氯胺酮对糖尿病神经痛大鼠p38丝裂原活化蛋白激酶表达的影响 |
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| 引用本文： | 柯昌斌,黄晓霞,李元涛,秦成名,罗向红,刘菊英. 氯胺酮对糖尿病神经痛大鼠p38丝裂原活化蛋白激酶表达的影响[J]. 郧阳医学院学报, 2008, 27(5) |
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| 作者姓名： | 柯昌斌 黄晓霞 李元涛 秦成名 罗向红 刘菊英 |
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| 作者单位： | [1]郧阳医学院附属太和医院麻醉科,湖北十堰442000 [2]郧阳医学院附属太和医院肾病内科,湖北十堰442000 |
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| 基金项目： | 湖北省卫生厅重大科研基金 |
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| 摘 要： | 目的:观察氯胺酮对糖尿病神经病理痛大鼠神经系统中p38丝裂原活化蛋白激酶(p38MAPK)的影响,探讨其作用的信号机制。方法:16只雌性Wistar大鼠注射链脲菌素复制糖尿病神经病理痛模型。随机分为糖尿病组(D组)和氯胺酮组(K组),另设对照组(C组)。K组大鼠经氯胺酮处理。均测机械痛阈和神经传导速度(NCV),免疫组化和ELISA法检测脊髓和背根神经节(DRG)磷酸化p38MAPK(p-p38MAPK)水平。结果:与对照组比较,糖尿病组和氯胺酮组MWT和NCV均下降,脊髓和DRG中p-p38MAPK水平均升高(P<0.05),但糖尿病组变化幅度明显(P<0.05)。结论:氯胺酮对大鼠糖尿病神经病理痛有疼痛治疗和神经保护作用,其机制可能是阻断p38MAPK信号通路。
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| 关 键 词： | p38 MAPKs 糖尿病神经病变 氯胺酮 |
Effects of Ketamine on Expression of p38 Mitogen-Activated Protein Kinase in Diabetic Peripheral Neuropathy Rats |
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| KE Chang-bin,HUANG Xiao-Xia,LI Yuan-Tao,QIN Cheng-ming,LUO Xiang-hong,LIU Ju-ying. Effects of Ketamine on Expression of p38 Mitogen-Activated Protein Kinase in Diabetic Peripheral Neuropathy Rats[J]. Journal of Yunyang Medical College, 2008, 27(5) |
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| Authors: | KE Chang-bin HUANG Xiao-Xia LI Yuan-Tao QIN Cheng-ming LUO Xiang-hong LIU Ju-ying |
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| Affiliation: | KE Chang-bin1,HUANG Xiao-Xia2,LI Yuan-Tao1,QIN Cheng-ming1,LUO Xiang-hong1,LIU Ju-ying1(1Departmaent of Anesthesiology,2Department of Nephrology,Taihe Hospital,Yunyang Medical College,Shiyan,Hubei 442000,China) |
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| Abstract: | Objective To observe the effect of ketamine on expression of p38Mitogen-Activated Protein Kinase(p38MAPK)in diabetic peripheral neuropathy rats.Methods The diabetic peripheral neuropathy model was established by injecting streptozotocin in 16 female Wistar rats,then randomly divided into three groups:diabetic neuropathic pain group(D group),ketamine group(K group)treated with ketamine,and control group(C group).Paw withdrawal mechanical threshold(MWT)and nerve conduction velocity(NCV)were measured.The level... |
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| Keywords: | p38MAPKs |
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