| 山东省人类肠道致细胞病变孤儿病毒13型分离株的基因特征分析 |
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| 引用本文： | 毛乃颖,王海岩,朱贞,李岩,纪峰,陶泽新,崔爱利,许文波.山东省人类肠道致细胞病变孤儿病毒13型分离株的基因特征分析[J].中国计划免疫,2009,15(3):238-241. |
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| 作者姓名： | 毛乃颖 王海岩 朱贞 李岩 纪峰 陶泽新 崔爱利 许文波 |
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| 作者单位： | 毛乃颖,朱贞,崔爱利,许文波(中国疾病预防控制中心病毒病预防控制所,病毒基因工程国家重点实验室,世界卫生组织两太平洋区麻疹参比实验室,北京,100050);王海岩,李岩,纪峰,陶泽新(山东省疾病预防控制中心,济南,250014)
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| 基金项目： | 世界卫生组织西太平洋区脊髓灰质炎参比实验室经费项目，卫生部疾病预防控制专项基金 |
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| 摘 要： |
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| 关 键 词： | 人类肠道致细胞病变孤儿病毒13型 分子流行病学分析 |
The Genetic Characterization of Enteric Cytopathic Human Orphanviruses Type 13 Isolated in Shandong Province |
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| Institution: | MAO Nai-ying, WANG Hai-yan, ZHU Zhen, et al. (World Health Organization Western Pacific Region Regional Reference Measles Laboratory, State Key Laboratory for Molecular ＆ Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China) |
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| Abstract: | Objective To analysis the genetic characteristics of Echo 13 isolated from stool specimens of AFP patient in Shandong. Methods The complete VP1 sequences of the 6 isolates were successfully amplified by RT-PCR and were compared with other Echovirus 13 isolates available from GenBank. Results 6 Shandong isolates were clearly identified as Echo 13 and were grouped into B cluster that agreed with neutralization result. The homogeneity analysis showed that the Shandong isolates share at least 80% similarity in nucleotide level and 94.4% in amino acid level. Phylogenetic tree base on complete VP1 sequence indicated there were many transmitting chains of Echovirus 13 prevailed in China. Conclusion All Echo13 isolates were divided into three genomic clusters A, B and C. It is suggested that enterovirus surveillance should be strengthened to prevent imported of Echo 13. |
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| Keywords: | Entric Cytopathic Human Orphanviruses Type 13 Molecular epidemiology |
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