| 白血病抑制因子在子宫内膜异位症并发不孕患者黄体中期子宫内膜中的表达 |
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| 引用本文： | 王琳,史常旭,常青,粱志清.白血病抑制因子在子宫内膜异位症并发不孕患者黄体中期子宫内膜中的表达[J].生殖与避孕,2002,22(6):355-357,T002. |
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| 作者姓名： | 王琳 史常旭 常青 粱志清 |
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| 作者单位： | 第三军医大学西南医院妇产科,重庆.400038 |
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| 摘 要： | 目的:探讨白血病抑制因子(LIF)在子宫内膜异位症(EM)导致不孕机制中的作用。方法:采用原位杂交及免疫组织化学方法对15例异位症并发不孕患者黄体中期子宫内膜中的LIF mRNA及其蛋白的表达进行定位及半定量分析,并以15例有生育妇女作为对照组。结果:子宫内膜异位症组LIF mRNA平均光密度为3.12±0.32,LIF蛋白平均光密度为9.31± 2.10,显著低于对照组的6.25±2.14与15.70±1.52(P<0.05)。结论:子宫内膜异位症组黄体中期子宫内膜LIF表达下降可能是其不孕的原因之一。
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| 关 键 词： | 子宫内膜异位症 白血病抑制因子 不孕症 子宫内膜 |
| 文章编号： | 0253-357X(2002)06-0355-003 |
Expression of Leukemia Inhibitory Factor in Luteal Middle Phase Endometrium of Infertile Women with Endometriosis |
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| WANG Lin SHI Chang-xu CHANG Qing LIANG Zhi-qing.Expression of Leukemia Inhibitory Factor in Luteal Middle Phase Endometrium of Infertile Women with Endometriosis[J].Reproduction and Contraception,2002,22(6):355-357,T002. |
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| Authors: | WANG Lin SHI Chang-xu CHANG Qing LIANG Zhi-qing |
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| Abstract: | Objective: To evaluate the possible role of leukemia inhibitory factor (LIF) in infertile women with endometriosis. Methods: By immunohistochemical analysis and in situ hybridization,the LIF mRNA and protein expressions were determined and semi-quantitatively analyzed in luteal middle phase endometrium of infertile women with endometriosis. Data was compared with 15 normal fertile women without endometriosis in control group. Results: Mean optical density of LIF mRNA and LIF protein was significant lower in endometriosis group than in the control group. Conclusion: Expression of LIF in luteal middle phase endometrium of infertile women with endometriosis is reduced and it may be a possible cause of infertility with endometriosis. |
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| Keywords: | endometriosis leukemia infertility endometrium |
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