1,25-dihydroxyvitamin D3 inhibits proliferation of human promyelocytic leukaemia (HL60) cells and induces monocyte-macrophage differentiation in HL60 and normal human bone marrow cells |
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| Authors: | Donald M. McCarthy Jesus F. San Miguel Hedley C. Freake Philip M. Green Heddy Zola Daniel Catovsky John M. Goldman |
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| Affiliation: | 1. MRC Leukaemia Unit, Royal Postgraduate Medical School, Hammersmith Hospital, Hammersmith, London, U.K.;2. Department of Chemical Pathology, Royal Postgraduate Medical School, Hammersmith Hospital, Hammersmith, London, U.K.;3. Flinders Medical Centre, Bedford Park, South Australia |
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| Abstract: | 1,25-dihydroxyvitamin D3 induces monocyte-macrophage differentiation and inhibits proliferation of cells from the human promyelocytic leukaemia cell line HL60. Similarly human bone marrow progenitor cells differentiate preferentially along the monocyte-macrophage pathway when incubated in the presence of 1,25-dihydroxyvitamin D3. We suggest that the inhibition of growth which occurs after addition of the vitamin to HL60 might be paralleled in vivo by inhibition of proliferation of leukaemic cells; also we speculate that the vitamin may be involved in the control of both monocyte-macrophage and osteoclast production in vivo. |
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| Keywords: | HL60 1 monocytes macrophages |
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