5-羟色胺对大鼠脊髓场电位的影响

用银球电极在麻醉、麻痹大鼠腰膨大处记录刺激腓神经引起的脊髓场电位(SFP),观察其在5-HT作用下的变化状况。结果表明,在本实验剂量下,腹腔注射左旋-5羟色胺酸(L-5HTP)后SFP未见显著改变;静脉注射L-5HTP后SFP的N、P波出现显苫升高或显著降低两种变化;局部施加5-HT后,N、P波只出现显著降低;A波在任何处理中均未见到显著改变。结果提示,5-HT可能主要通过抑制中间神经元的活动和以突触前及(或)突触后抑制作用影响N、P波的形成。

Effect of 5-hydroxytryptamine on Spinal Field Potential in the Rat

The experiments were carried on anesthetized and immobilized rats, and the change of spinal field potentials (SFP) was observed when L- 5HTP or 5-HT was given. No change was seen in SFP during intraperi- tonial injection of L-5HTP solution. The amplitudes of waves N and P reduced or increased in equal number following intravenous injection of L-5HTP.Only decrease in magnitude of waves N and P was shown when 5-HT was locally applied. No change in wave A's amplitude could be observed in all experimental groups. The results indicate that 5-HT may influence formation of waves N and P mainly via suppression of the activity of interneurons as well as pre-and/or postsynaptic inhibition.