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Acute hepatic failure due to hepatosplenic B-cell non-Hodgkin's lymphoma in a patient infected with hepatitis C virus
Authors:Masahide Yoshikawa  Yoshiko Yamane  Satoshi Yoneda  Shu Iwasawa  Kimio Nishimura  Hiroshi Kawamoto  Hiroshi Nakano  Hiroshi Fukui  Hirokazu Nakamine
Affiliation:(1) Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara 634-8522, Japan, JP;(2) Department of Clinico-Laboratory Diagnostics, Nara Medical University, 840 Shijo-cho, Kashihara 634-8522, Japan, JP;(3) Department of Internal Medicine, Takanohara General Hospital, Nara, Japan, JP;(4) Department of Laboratory Medicine, Wakayama Medical University,Wakayama, Japan, JP
Abstract:We report a 75-year-old Japanese man infected with hepatitis C virus (HCV) who died of acute hepatic failure due to the hepatic infiltration of B-cell non-Hodgkin's lymphoma (NHL) cells. He suddenly developed jaundice, fatigue, fever, and hepatosplenomegaly during the course of chronic infection with HCV. Postmortem liver necropsy revealed extensive infiltration of lymphoma cells into the liver. Although the association between HCV infection and NHL has recently become a matter of concern, we believe this to be the first reported case of acute hepatic failure caused by hepatic involvement of non-Hodgkin's lymphoma in an HCV-infected patient. (Received Jan. 12, 1998; accepted June 26, 1998)
Keywords:: hepatitis C virus  non-Hodgkin's lymphoma  acute hepatic failure  hepatosplenic lymphoma
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