奥替溴铵、匹维溴铵、马来酸曲美布汀和酪酸茵治疗肠易激综合征药物经济学研究

目的 初步探讨奥替溴铵（斯巴敏）、匹维溴铵（得舒特）、马来酸曲美布汀（舒丽启能）和酪酸菌（米雅BM）治疗肠易激综合征的药物经济学。方法 从中国生物医学文献数据库和学术期刊检索相关文献，选择符合标准（随机、双盲、安慰剂对照）的临床试验论文，提取临床试验数据，进行药物经济学评价。结果 服用斯巴敏40mg,tid,2wk药费71.16元；服用得舒特50mg,tid,2wk药费120.12元；服用舒丽启能200mg,tid,2wk药费110.46元；服用米雅BM80mg,tid,2wk药费282.24元。产生单位效果所需的成本分别为斯巴敏80.86；得舒特143.17；舒丽启能135.37；米雅BM351.04。以斯巴敏治疗成本最低。结论 斯巴敏是治疗肠易激综合征最优的选择。

Pharmacoeconomic analysis of otilonium Br, pinaverium Br, trimebutine maleate and clostridium butyricum for treatment of irritable bowel syndrome patients

Aim To evaluate the economics of otilonium Br (Spasmomen), pinaverium Br (Dicetl), trimebutine maleate (Cerekinon) and clostridium butyricum (Miya-BM) in the treatment of irritable bowel syndrome patients.Methods Research papers were selected according to the criteria of randomized, double-blinded, placebo-controlled clinical trial from CBM-Data and academic journals.The trial data in these papers were extracted and the cost-effectiveness analysis was conducted. Results The regime of Spasmomen 40 mg,tid for 2 wk cost $71.16. The regime of Dicetel 50 mg, tid for 2 wk cost $120.12. The regime of Cerekinon 200mg, tid for 2 wk cost $110 46. The regime of Miya-BM 80 mg, tid for 2 wk cost $282.24.The cost-effectiveness of Spasmomen, Dicetel, Cerekinon and Miya-BM was 80.86, 143.17,135.37 and 351.04 respectively.The cost of Spasmomen getting the same effect was the lowest of above 4 regimes.Conclusion The regime of Spasmomen is the best choice for the treatment of irritable bowel syndrome patients.