Effects of Gamma-Globulin on the Cardiac Sequelae of Kawasaki Disease |
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Authors: | H Yanagawa Z Tuohong I Oki Y Nakamura M Yashiro T Ojima S Tanihara |
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Institution: | (1) Department of Public Health, Jichi Medical School, 3311 Yakushiji, Minamikawachi-machi, Tochigi-ken 329-0498, Japan, JP |
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Abstract: | Our aim was to delineate the effect of various factors, such as sex, age, serum albumin levels, and the timing of gamma-globulin
(GG) therapy, on cardiac sequelae of Kawasaki disease. The patients with Kawasaki disease who were reported at the 1995–1996
nationwide survey and received 2000 mg/kg at specified hospitals were selected as the subjects of the study. A total of 2221
patients actually received the basic dose. The relationships of the GG therapy with the cardiac sequelae, sex, age, timing
of GG administration (the date of initiation and duration of the regimen following disease onset), and serum albumin levels
were examined by using logistic regression analysis. The odds ratios for the cardiac sequelae in patients with Kawasaki disease
were high in males (1.63), in those under the age of 1 year (1.54), and in those with a serum albumin level <3.2 g/dl (2.64).
The odds ratio was low in those who received GG before day 8 of the illness (0.69) or in those for whom the administration
period was for 2 days or less (0.67). To prevent cardiac sequelae of Kawasaki disease it is desirable that GG therapy be started
as soon as possible and completed within 2 days. |
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Keywords: | : Kawasaki disease — Gamma-globulin treatment — Epidemiology — Cardiac sequelae |
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