| 雄激素致不孕大鼠卵巢血红素加氧酶蛋白的表达 |
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| 引用本文： | 马惠荣,杜惠兰,宋翠淼,高永刚,杨秀芳,李国明.雄激素致不孕大鼠卵巢血红素加氧酶蛋白的表达[J].医学理论与实践,2008,21(9):995-997. |
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| 作者姓名： | 马惠荣 杜惠兰 宋翠淼 高永刚 杨秀芳 李国明 |
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| 作者单位： | 1. 河北医科大学,中西医结合学院,河北石家庄,050091
2. 河北医科大学基础医学院,河北石家庄,050091 |
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| 基金项目： | 教育部留学回国人员科研启动基金 |
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| 摘 要： | 目的:研究血红素加氧酶蛋白在雄激素致不孕模型大鼠卵巢的表达。方法:9日龄SD雌性大鼠颈背部皮下注射丙酸睾丸酮制造无排卵不孕模型,3~4月龄时选取动情前期断头处死,采用免疫组化法,观察并比较血红素加氧酶蛋白在ASR和正常大鼠卵巢的表达。结果:与正常组相比,HO-1和HO-2在ASR卵巢颗粒细胞表达减弱,在ASR泡膜细胞表达增强。结论:ASR无排卵的发生可能与血红素加氧酶两个亚型的表达异常有关。
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| 关 键 词： | 血红素加氧酶 雄激素致无排卵模型大鼠 卵巢 免疫组化法 |
The Expression of HO in Ovary of Androgen Induced Sterile Rats |
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| MA Huirong,DU Huilan,SONG Cuimiao,et al..The Expression of HO in Ovary of Androgen Induced Sterile Rats[J].The Journal of Medical Theory and Practice,2008,21(9):995-997. |
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| Authors: | MA Huirong DU Huilan SONG Cuimiao |
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| Institution: | MA Huirong,DU Huilan,SONG Cuimiao,et al.Integrated Traditional and Western Medical College,Hebei Medical University,Shijiazhuang 050091 |
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| Abstract: | Objective：To localize the expression of heine oxygenase（HO） proteins in androgen induced sterile rats （ASR）ovary to investigate the effect of HO on development of anovulatory condition. Methods： The anovulatory model was established by subcutaneous injection of testoserone propionate to SD female rats of 9-day age. The rats of 3-4 months old at the preoestrus were euthanized, and the expression and distribution patterns of HO-1 and HO-2 in ASR and normal SD rats in ovary were observed by means of immunocytochemistry and compared between the two groups, Results：Compared with normal group, there were weak expression of HO-1 protein in granulosa cells and strong expression of HO-2 protein in theca cells. Conclusion. There may be correlation between the abnormal distribution of HO and the development of anovulatory condition. |
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| Keywords: | HO ASR Ovary Immunocytochemistry |
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