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Accelerated liver recovery after acute CCl4 poisoning in rats treated with sodium phthalhydrazide |
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| Institution: | 1. Institute of Immunology and Physiology of the Ural Branch of the RAS, Yekaterinburg, Russian Federation;2. Ural Federal University Named After the First President of Russia B.N. Yeltsin, Yekaterinburg, Russian Federation;3. Federal State Budget Educational Institution of Higher Education «Ural State Medical University» of the Ministry of Health of the Russian Federation, Yekaterinburg, Russian Federation;4. Institute of Immunopathology and Preventive Medicine, Povsetova ulica 29, 1000 Lublana, Slovenia |
| Abstract: | Pharmacotherapy of hepatobiliary disorders is an important issue due to the high prevalence of liver failure, toxic and viral hepatitis and cirrhosis. The number of stimuli that can potentially induce or accelerate liver recovery is limited; in our study we selected sodium phthalhydrazide, which has been found to promote liver regeneration after partial hepatectomy. We examined the effects of phthalhydrazide on liver morphometric, histological and biochemical parameters in rats intoxicated with CCl4. Accelerated liver recovery after CCl4 intoxication in phthalhydrazide-treated animals was evidenced by increased number of liver sinusoidal cells, reduced focal necrosis of hepatocytes and reduced perifocal leukocyte infiltration. Decreased plasma levels of pro-inflammatory cytokines TNF-α and IL-18 and decreased concentrations of IL-6 and IFN-γ in liver homogenates were associated with reduced severity of cholestasis and normalized hepatic protein synthesis in CCl4-intoxicated rats exposed to phthalhydrazide. Anti-inflammatory and immunomodulating properties of phthahlhydrazide can be an important factor contributing to accelerated liver recovery at early stages of acute CCl4-toxic liver impairment. |
| Keywords: | Liver regeneration Liver recovery Hepatoprotective pharmaceuticals Phthalhydrazide Sinusoidal cells Mast cells Cytokines carbon tetrachloride DAMPs"} {"#name":"keyword" "$":{"id":"k0055"} "$$":[{"#name":"text" "_":"damage-associated molecular patterns ALT"} {"#name":"keyword" "$":{"id":"k0065"} "$$":[{"#name":"text" "_":"alanine aminotransferase AST"} {"#name":"keyword" "$":{"id":"k0075"} "$$":[{"#name":"text" "_":"aspartate aminotransferase ALP"} {"#name":"keyword" "$":{"id":"k0085"} "$$":[{"#name":"text" "_":"alkaline phosphatase ATP"} {"#name":"keyword" "$":{"id":"k0095"} "$$":[{"#name":"text" "_":"adenosine triphosphate HBV"} {"#name":"keyword" "$":{"id":"k0105"} "$$":[{"#name":"text" "_":"hepatitis B virus HCV"} {"#name":"keyword" "$":{"id":"k0115"} "$$":[{"#name":"text" "_":"hepatitis C virus IL-1"} {"#name":"keyword" "$":{"id":"k0125"} "$$":[{"#name":"text" "_":"interleukin-1 IL-6"} {"#name":"keyword" "$":{"id":"k0135"} "$$":[{"#name":"text" "_":"interleukin-6 IL-10"} {"#name":"keyword" "$":{"id":"k0145"} "$$":[{"#name":"text" "_":"interleukin-10 IL-18"} {"#name":"keyword" "$":{"id":"k0155"} "$$":[{"#name":"text" "_":"interleukin-18 TNF-α"} {"#name":"keyword" "$":{"id":"k0165"} "$$":[{"#name":"text" "_":"tumor necrosis factor-alpha TGF-β1"} {"#name":"keyword" "$":{"id":"k0175"} "$$":[{"#name":"text" "_":"transforming growth factor beta-1 IFN-γ"} {"#name":"keyword" "$":{"id":"k0185"} "$$":[{"#name":"text" "_":"interferon gamma |
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