| 乳腺癌中nm 23-H1 mRNA及其蛋白低表达的研究 |
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| 引用本文： | 刘玉忠,郭淑贞,郭文斌,庄熙晶. 乳腺癌中nm 23-H1 mRNA及其蛋白低表达的研究[J]. 中国医师进修杂志, 2000, 23(6) |
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| 作者姓名： | 刘玉忠 郭淑贞 郭文斌 庄熙晶 |
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| 作者单位： | 1. 大连市中心医院,普外二科,辽宁,大连,116033
2. 大连市辛寨子地区医院,辽宁,大连,116033 |
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| 摘 要： | 目的 :为探讨nm 2 3-H1mRNA及其蛋白低表达之间相关性及与乳腺癌生物学行为的关系。方法 :应用RT/PCR及免疫组化方法对 5 8例乳腺癌中nm2 3-H1mRNA及其蛋白的表达进行检测。结果 :分别为 44 8% ,48 2 %的乳腺癌伴有nm2 3 -H1mRNA或该基因编码蛋白的低表达 ;nm2 3-H1mRNA与其蛋白表达虽有相关性 ,但并不完全吻合。低水平的nm2 3-H1mRNA或其蛋白与乳癌淋巴结转移呈显著相关。结论 :通过nm2 3 -H1水平的检测对乳癌的转移潜能及预后的判断有较重要的意义
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| 关 键 词： | 乳腺肿瘤 nm23基因 基因表达 |
LOW EXPRESSION OF nm23-H1 mRNA AND ITS PROTEIN IN BREAST CANCER |
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| LIU Yuzhong,GUO Shuzhen,GUO Wenbin,et al.. LOW EXPRESSION OF nm23-H1 mRNA AND ITS PROTEIN IN BREAST CANCER[J]. Chinese Journal of Postgraduates of Medicine, 2000, 23(6) |
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| Authors: | LIU Yuzhong GUO Shuzhen GUO Wenbin et al. |
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| Abstract: | Objective:To explore the expression of nm23-H 1 mRNA and its protein in breast cancer and its correlation to the biologic behavior.Method:RT-PCR and immunohistochemical method were explore to detect expression of nm23-H 1 mRNA and the protein in 58 breast cancer.Results:Low level expression of nm23-H 1 mRNA and the protein was showed in 44.8% and 48.2% of examinated cases respectively.The low expression of nm23-H 1 mRNA was correlated with,but not always paralle to the protein expression.The low level expression of nm23-H 1 mRNA or the protein was significantly associated with lymphatic metastasis.Conclusion:It is useful to examine nm23-H 1 expression for evaluating metastatic potential and prognosis of the breast cancer. |
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| Keywords: | breast carcinoma metastasis-suppressor gene gene expression |
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