| 咪唑斯汀治疗6970例慢性荨麻疹临床研究 |
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| 引用本文： | 皿治林治疗荨麻疹全国多中心临床协作组. 咪唑斯汀治疗6970例慢性荨麻疹临床研究[J]. 中华皮肤科杂志, 2003, 36(6): 340-341 |
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| 作者姓名： | 皿治林治疗荨麻疹全国多中心临床协作组 |
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| 作者单位： | The Clinical Cooperation Group，YU bi-e*，LIAO Kang-huang.* Huashan Hospital，Fudan University，Shanghai200040，China |
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| 摘 要： | 目的观察咪唑斯汀治疗慢性荨麻疹的疗效和安全性。方法口服咪唑斯汀10mg,每日1次,连服14d为1个疗程。结果用咪唑斯汀治疗6970例慢性荨麻疹患者,总有效率治疗7d为49.0%,14d达85.0%。治疗后患者的瘙痒、风团大小和数量均有明显改善,治疗7d和14d时分别与治疗前比较,治疗14d时与治疗7d时比较,差异均有非常显著性(P<0.001)。治疗1d后半数患者的症状和体征开始缓解,3d后80%以上出现改善。不良反应少,主要表现为困倦(6.8%,与一般安慰剂的发生率相同)和头晕(1.4%)。结论咪唑斯汀治疗慢性荨麻疹有效而安全。
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| 关 键 词： | 咪唑斯汀 慢性荨麻疹 临床研究 安全性 不良反应 |
| 修稿时间： | 2002-04-02 |
Therapeutic Effect of Mizolastine in the Treatment of 6 970 Patients with Chronic Urticaria |
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| The Clinical Cooperation Group,YU bi-e,LIAO Kang-huang. Therapeutic Effect of Mizolastine in the Treatment of 6 970 Patients with Chronic Urticaria[J]. Chinese Journal of Dermatology, 2003, 36(6): 340-341 |
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| Authors: | The Clinical Cooperation Group YU bi-e LIAO Kang-huang |
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| Affiliation: | The Clinical Cooperation Group,YU bi-e*,LIAO Kang-huang.* Huashan Hospital,Fudan University,Shanghai200040,China |
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| Abstract: | Objective To study the efficacy and safety of mizolastine in the treatment of chronic urticaria.Methods With oral mizolastine,10mg daily,all patients received14days treatment as a course.Results The total effective rate of49.0%were found in7days,and85.0%in14days after initiation of treatment with mizolastine in6970chronic urticaria patients.The improvement of itching and wheals,after7days and14days treatment,was significantly higher than before treatment,respectively(P<0.001).It was found that half of the patients improved after1d treatment,and80%patients improved after3days.Ad-verse reactions were mild,mainly sleepiness(6.8%,similar to placebo)and dizziness(1.4%).Conclusion Mizolastine is an effective and safe drug in treating chronic urticaria. |
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| Keywords: | Urticaria Histamine antagonists |
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