Changes of peripheral blood lymphocyte subsets in a long-term survivor with advanced renal cell carcinoma |
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Authors: | Koji Yoshimura Tamio Yamauchi Hiroshi Maeda Tsuneo Kawai |
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Affiliation: | (1) Department of Urology, Cancer Institute Hospital, Kami-Ikebukuro 1-37-1, Toshima-ku, 170 Tokyo, Japan |
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Abstract: | We present the case of an 11-year survivor with advanced renal cell carcinoma (T4N2M1). This patient received long-term interferon-alpha (IFN-α)-based immunotherapy. Measurement of peripheral blood lymphocyte subsets suggested that reduction of the IFN-α dose might be associated with a marked increase of cytotoxic T cells, suppressor T cells, activated suppressor/cytotoxic T cells, and natural killer cells among the peripheral blood lymphocytes. |
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Keywords: | renal cell carcinoma immunotherapy interferon-alpha peripheral blood lymphocyte subsets |
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