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INDUCTION AND PROMOTION OF γ-GLUTAMYLTRANSPEPTIDASE-POSITIVE FOCI IN THE RAT LIVER BY METHYLGLYOXAL |
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| Authors: | Antonietta Martelli Marco Ghia Eugenio Mereto Umberto Maria Marinari Giovanni Brambilla |
| Affiliation: | Institute of Pharmacology, University of Genoa, Viale Benedetto XV-2, I-16132 Genoa, Italy;Institute of General Pathology, University of Genoa, Viale Benedetto XV-2, I-16132 Genoa, Italy |
| Abstract: | The effect of pre-(initiation) and post-(promotion) administration of methylglyoxal (MG) on the induction of γ-glutamyltranspeptidase (GGT)-positive foci in the liver of F344 male rats was investigated. GGT-positive foci were produced in doserelated amounts by 0.05 and 0.2% MG in drinking water, either when administered to uninitiated rats or when given in the promotion phase. |
| Keywords: | Methylglyoxal γ-Glutamyltranspeptidase-positive foci Rat liver |