Mitochondrial function in bone resorption and formation

Mitochondria are involved in diverse biological processes through energy production, ROS generation and apoptosis, and mitochondrial dysfunction causes metabolic disorders, neurodegenerative disease, cancer and aging. Recent evidence links mitochondrial function to bone cell activity, especially bone-resorbing ostroclasts. Mitochondria of bone cells may provide a clue to the understanding of the pathogenesis of bone disease and also for development of new treatment options.