基质金属蛋白酶-7在胃癌中表达的意义

目的:研究基质金属蛋白酶-7(MMP-7)在胃癌癌旁和癌巢组织中的表达及其与胃癌浸润转移、分化、分期的关系。方法:用免疫组织化学的方法检测MMP-7在10例癌旁组织和46例胃癌组织中的表达,并结合临床病理资料进行分析。结果:胃癌组织中MMP-7的阳性表达率为71.7%(33/46),而癌旁组织中仅有1例MMP-7弱表达;在胃癌组织中MMP-7的阳性表达在浸润深度、TNM分期、淋巴结转移和脉管浸润中有显著性意义(均P<0.05),而在肿瘤大小、肿瘤分化和Lauren分型中无显著性意义(均P>0.05)。结论:MMP-7基因的高表达与胃癌的浸润深度、淋巴结转移和临床分期相关,可能成为胃癌恶性行为的生物学标记物。

Expression of Matrix Metalloproteinase-7 in Gastric Cancer

Objective: To study the expression of matrix metalloproteinase-7(MMP-7) in gastric carcinoma and paracarcinoma tissues,and its relationship with lymphatic metastases,TNM stages and cell differentiation.Methods: MMP-7 expression was immunohistochemically examined in 46 gastric cancer and 10 paracarcinoma tissues,then the relationship between the expression of MMP-7 and clinicopathological features was analyzed.Results: The MMP-7 positive rate in gastric cancer was 71.7%(33/46),while in the paracarcinoma tissues,weak MMP-7 expression was only detected in one case.Significant difference between carcinoma and paracarcinoma tissue was found in the TNM stages, depth of invasion,lymphatic metastases and infiltration of vessels,whereas there was no significant difference in the cell differentiation,histological type and the diameter of tumour.Conclusion: The expression of MMP-7 in gastric cancer was correlated to tumor invasion and TNM classification,moreover,MMP-7 may be a useful marker for determining the biological aggressiveness of gastric cancer.