| 雷米普利对离体工作心脏及抗心肌缺血的作用 |
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| 引用本文： | 郭莲军,胡文淑,向继洲,江明性. 雷米普利对离体工作心脏及抗心肌缺血的作用[J]. 华中科技大学学报(医学版), 1991, 0(1) |
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| 作者姓名： | 郭莲军 胡文淑 向继洲 江明性 |
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| 作者单位： | 同济医科大学基础医学部药理学教研室(郭莲军，胡文淑，向继洲)，同济医科大学基础医学部药理学教研室(江明性) |
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| 摘 要： | 雷米普利及其双酸制剂在10~(-5)mol/L时,对离体豚鼠工作心脏各心功能参数均无明显影响。将以上两种制剂分别静脉注射和腹腔注射2mg/kg,20min后可改变垂体后叶素所致的大鼠急性心肌缺血时的心电图,减少大鼠结扎冠状动脉所致心肌梗塞区域。结果表明:雷米普利及其双酸制剂对离体豚鼠心肌收缩性能无明显作用,而对急性心肌缺血似有一定保护作用。
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| 关 键 词： | 雷米普利 冠状动脉疾病 离体工作心脏 药理学 |
Effects of Ramipril on Isolated Working Quinea Pig Heart and Myocardial Infarction in Rats |
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| Guo Lianjun,Hu Wenshu,Xiang Jizhou,Jiang Mingxing. Effects of Ramipril on Isolated Working Quinea Pig Heart and Myocardial Infarction in Rats[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1991, 0(1) |
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| Authors: | Guo Lianjun Hu Wenshu Xiang Jizhou Jiang Mingxing |
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| Affiliation: | Guo Lianjun,Hu Wenshu,Xiang Jizhou,Jiang MingxingDepartment of Pharmacology,Faculty of Basic Medical Sciences,Tongjl Medicai University,Wuhan |
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| Abstract: | Various cardiac function parameters in isolated working quinea pig heart were not affected by Ramipril and Diacid-ramipril 10-5 mol/L. Ramipril and Diacid-ramipril 2 mg/kg iv and ip, respectively, changed ECG of pituitrin (1 U/kg, iv) induced acute myocardial ischemia in rats, decreasing the size of infarction by coronary ligation in rats The above findings suggest that Ramipril and Diacid-ramipril effectively protect animal from experimental infarction. |
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| Keywords: | ramipril coronary disease isolated working quinea pig heart pharmacology |
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