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奥卡西平治疗创伤性癫痫的疗效观察和安全性分析
引用本文:王学玲,赵永青,张赛. 奥卡西平治疗创伤性癫痫的疗效观察和安全性分析[J]. 武警医学院学报, 2010, 19(4): 263-266
作者姓名:王学玲  赵永青  张赛
作者单位:1. 天津医科大学研究生院,天津,300070
2. 武警医学院附属医院脑系科中心,天津,300162
基金项目:武警医学院博士启动金科研课题 
摘    要:【目的】观察奥卡西平(oxcarbazepine,OXC)治疗创伤性癫痫(posttraumatic epilepsy,PTE)的临床疗效和安全性。【方法】连续性收集2007年3月-2008年9月期间在我院癫痫中心就诊符合入选条件的66例创伤性癫痫患者,10例未曾接受任何抗癫痫治疗和46例曾治疗不规范的患者调整为OXC单药治疗,10例曾服用德巴金的患者联合应用OXC,单药剂量维持量调整在600~1500mg,联合用药的维持量在600~1200mg。自身对比开放性观察12个月,评价OXC对创伤性癫痫的发作控制率、脑电图改善情况、不良反应和安全性。【结果】OXC对创伤性癫痫总有效率为85.94%,控制率为56.25%,治疗前后脑电图比较结果显示,治疗12个月后脑电图得到明显改善(P〈0.01)。常见的不良反应包括:头昏、嗜睡、无力、头痛、恶心、食欲下降、白细胞下降、手颤和皮疹。因不良反应而停药者2例,占3.03%。患者治疗前、治疗后不同时间血常规、肝肾功能和心电图对比均无明显变化(P〉0.05)。【结论】奥卡西平对66例创伤性癫痫患者的治疗效果较明显,不良反应轻,安全性高。

关 键 词:奥卡西平  创伤性癫痫  临床疗效  安全性

The efficacy and safety of Oxcarbazepine on posttraumatic epilepsy
WANG Xue-ling,ZHAO Yong-qing,ZHANG Sai. The efficacy and safety of Oxcarbazepine on posttraumatic epilepsy[J]. Acta Academiae Medicinae CPAPF, 2010, 19(4): 263-266
Authors:WANG Xue-ling  ZHAO Yong-qing  ZHANG Sai
Affiliation:WANG Xue-ling,ZHAO Yong-qing,ZHANG Sai (Tianjin Medical University,Tianjin 300070,China)
Abstract:[Objective]To observe the efficacy and safety of Oxcarbazepine (OXC) in treating posttraumatic epilepsy (PTE). [Method]66 cases of posttraumatic epilepsy was continuously treated at Epilepsy Center of our hospital from March 2007 to September 2008. Among which,10 cases had not received any AEDs treatment and 46 cases had treated with non-standard before and received single OXC drug treatment,10 cases had taken Depakine combined with OXC,monotherapy's dose maintained at 600~1 500 mg and combination therapy dose maitained at 600~1 200 mg. Comparison of open self-observation for 12 months,the control rate of OXC to seizures,the improvement of EEG and the adverse reactions and safety were evaluated. [Results]The total effective rate of OXC for posttraumatic epilepsy was 85.94%,the control rate was 56.25%,compared the results of EEG before and after treatment showed that EEG was significantly improved after 12 months of treatment(P 0.01). Common adverse reaction were dizziness,lethargy,inability,headache,nausea,loss of appetite,leukopenia,tremor and rash. Withdrawal due to adverse drug reactions in 2 cases and accounting for 3.03%. The routine blood test,liver and kidney function and ECG had no significant changes before and after treatment(P 0.05). [Conclusions]In 66 of cases posetraumatic epilepsy is treating with oxcarbazepine effective,high security and with mild adverse reaction.
Keywords:Oxcarbazepine  Posttraumatic Epilepsy  Efficacy  Safety  
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