Antiplasmodial activity of ineupatorolides A from Carpesium rosulatum |
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Authors: | Hyung-In Moon |
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Institution: | (1) National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA |
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Abstract: | Samples of Carpesium genus used as traditional remedies for the treatment of parasite infections were collected, and methanol extracts were obtained
by sonication. The ethylacetate-, n-butanol- and H2O-soluble fractions exhibited weak antiplasmodial activity (IC50 > 100 μg/ml; IC50, 50% inhibitory concentration). However, the chloroform fraction exhibited more impressive antiplasmodial activity (IC50 = 8.2 μg/ml). The antiplasmodial activity of the chloroform fractions was evaluated in vitro against the chloroquine-resistant
D10 strain of Plasmodium falciparum. Bioactivity-guided isolation of the chloroform fractions of the whole plants of Carpesium rosulatum has led to the isolation of a sesquiterpene lactone, ineupatorolides A, displaying high antiplasmodial activity (IC50 = 0.007 μg/ml). This is the first report of the isolation of ineupatorolides A from this species and of its remarkable antiplasmodial
activity. |
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