| 转移抑制基因及原癌基因在食管癌的表达及与预后的关系 |
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| 引用本文： | 王丰梅,郭新建,韩静琦,冶俊玲,赵文辉.转移抑制基因及原癌基因在食管癌的表达及与预后的关系[J].青海医药杂志,2007,37(5):9-11. |
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| 作者姓名： | 王丰梅 郭新建 韩静琦 冶俊玲 赵文辉 |
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| 作者单位： | 青海大学附属医院病理科,810001 |
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| 摘 要： | 目的:了解转移抑制基因(nm23-H1)和原癌基因(cerbB-2)在食管鳞癌表达与肿瘤临床、病理各指标间的关系.方法:用免疫组化的方法分析两个基因在91例食管癌(鳞癌84例,腺癌3例,未分化癌4例)的表达. 结果:nm23-H1和CerbB-2染色均定位于细胞浆,两者均与淋巴结转移、预后有显著相关性.在无淋巴结转移组,CerbB-2蛋白表达亦和预后有显著负相关.结论:认为nm23-H1高表达或CerbB-2低表达者,淋巴转移率低,术后生存率高,预后较好, CerbB-2可作为一个独立的预后指标,无论有无淋巴结转移,CerbB-2蛋白高表达预后均差.
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| 关 键 词： | 食管癌 免疫组化 nm23-H1 CerbB-2 |
Expression of Antimetastatic Gene nm23-H1 and Carcinoma gene CerbB-2 in Esophageal Carcinoma in relation to prognosis |
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| Wang Feng-mei,Guo Xing-jian,Han Jing-qi,Ye Jun-ling,Zhao Wen-hui.Expression of Antimetastatic Gene nm23-H1 and Carcinoma gene CerbB-2 in Esophageal Carcinoma in relation to prognosis[J].Qinghai Medical Journal,2007,37(5):9-11. |
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| Authors: | Wang Feng-mei Guo Xing-jian Han Jing-qi Ye Jun-ling Zhao Wen-hui |
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| Abstract: | Objective:To study the relationship between expression of nm23-H1 and CerbB-2 as well prognosis in esophageal carcinoma.Methods:expression of gene nm23-H1 and CerbB-2 were done by immunohistochemistry in 91 cases of esophageal carcinoma(84 cases of squamous carcinoma,3 cases of adenocarcinoma and 4 cases of undifferentiated small cell carcinoma).Results:Low rate of lymph node metastasis and high long term survival rate were found in the group with high expression of nm23-H1 or low expression of CerbB-2.In negative lymph node metastasis group,the expression of cerbB-2 was related to negative prognosis.Conclusions:There is a good prognosis if high nm23-H1 expression and low CerbB-2 expression were found in patients with esophageal carcinoma;and CerbB-2 can be an independent index as prognosis evaluation. |
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| Keywords: | nm23-H1 CerbB-2 |
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