皮肤性状改变后薄荷醇对甲硝唑透皮吸收作用的影响

目的：通过改变皮肤的性状，观察薄荷醇对甲硝唑透皮吸收的影响。方法：采用两室扩散池体外实验装置，以性状不同的兔皮作为屏障，使用薄荷醇作为促透剂，测定甲硝唑的吸光度，并计算人渗透系数，结果：当去除角质层后，薄荷醇对甲硝唑透皮吸收作用发生明显变化，与不含促透剂的完整皮肤组相比透皮作用非常显，但与本身不含促透剂组相比透皮作用不明显，同时薄荷醇和氮酮均能增加在完整皮肤中甲硝唑的贮存效应，对去角质层皮肤中甲硝唑的贮库效应无影响，结果还表明在两种不同性状的皮肤中，薄荷醇和氮酮对甲硝唑的透皮作用和贮库效应均无显差异。结论：薄荷醇能促进甲硝唑的透皮吸收，作用主要在角质层，角质层具贮库效应。

Effect of metronidazole on percutaneous absorption of l-menthol through changing the skin character in rabbits

AIM: To investigate the effect of l menthol on percutaneous absorption of metronidazole through changing the skin character in rabbits. METHODS: Using rabbit skin with different character as transdermal barrier, and l menthol as transdermal enhancer, the absorbance of metronidazole was determined with a two cells diffusion apparatus in vitro, and its permeability was figured out. RESULTS: The transdermal action of l menthol on percutaneous absorption of metronidazole was very evident when the corneum was eliminated; l menthol and azone could increase the desposit function of metronidazole in the intact skin, but had no effect on the skin without corneum. The result also showed that the percutaneous absorption and intact skins desposit function of metronidazole had no difference between l menthol and azone. CONCLUSION: L menthol can increase the percutaneous absorption of metronidazole. The site of the action is mainly the corneum which has desposit function.