| 山楂叶总黄酮对脑缺血的保护作用 |
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| 引用本文： | 张雷,邓同乐,严伟民,郑筱祥,匡荣,薛东.山楂叶总黄酮对脑缺血的保护作用[J].上海中医药杂志,2004,38(8):55-57. |
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| 作者姓名： | 张雷 邓同乐 严伟民 郑筱祥 匡荣 薛东 |
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| 作者单位： | 1. 浙江大学生物医学工程系,浙江,杭州,310027
2. 浙江省药品检验所,浙江,杭州,310004 |
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| 摘 要： | 为研究山楂叶总黄酮(Hawthorn Leaves Flavonoids，HLF)对脑缺血的保护作用。采用两种动物模型：①通过小鼠急性脑缺血模型，计算脑指数，检测脑组织内的丙二醛(MDA)、乳酸脱氢酶(LDH)、Na^ -K^ -ATP酶(Na^ -K^ -ATPase)和Ca^2 -ATP酶(Ca^2 -ATPase)的活性。②采用大鼠的大脑中动脉血栓模型(MCAO)，产生局灶性脑缺血，计算脑梗塞范围。结果显示，HLF降低了模型组小鼠脑指数、脑内MDA，升高了LDH、Na^ -K^ -ATPase和Ca^2 -ATPase的活性。提示HLF对小鼠脑缺血有一定的保护作用。
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| 关 键 词： | 山楂叶总黄酮（HLF） 脑缺血 脑梗塞范围 |
| 文章编号： | 1007-1334(2004)08-0055-03 |
| 修稿时间： | 2004年2月5日 |
Research of Protective Effect of Hawthorn Leaves Flavonoids on Brain Injury Resulting from Ischemia |
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| ZHANG Lei,DENG Tong-le,YAN Wei-min,ZHENG Xiao-xiang.Research of Protective Effect of Hawthorn Leaves Flavonoids on Brain Injury Resulting from Ischemia[J].Shanghai Journal of Traditional Chinese Medicine,2004,38(8):55-57. |
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| Authors: | ZHANG Lei DENG Tong-le YAN Wei-min ZHENG Xiao-xiang |
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| Institution: | ZHANG Lei DENG Tong-le YAN Wei-min ZHENG Xiao-xiang Department of Biomedical Engineering,Zhejiang UniversityKUANG Rong XUE Dong Zhejiang Provincial Institute of Drug Control |
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| Abstract: | To investigate the protective effect of Hawthorn Leaves Flavonoids (HLF) on cerebral ischemia models, the acute cere- bral ischemia model in mice was used, and the values of MDA, LDH, brain index (ratio of the brain weight with body weight) and the activity of Na+-K+-ATPase and Ca 2+-ATP- ase were observed; middle cerebral artery occlusion model was used, and the infarcted scope in brain was calculated. Results: The values of MDA and brain index were significantly raised, while the activity of LDH, Na+-K+-ATPase and Ca 2+-ATP- ase were declined remarkably, which were all antagonized by HLF; HLF also reduced significantly the infarcted scope in the brains. It is showed that HLF afforded protection against cerebral ischemia. HT6ZY] |
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| Keywords: | Hawthorn Leaves Flavonoids (HLF) cerebral ischemia MDA LDH Na+-K+-ATPase Ca 2+-ATPase infarcted scope |
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