| Affiliation: | (1) Department of Clinical Sciences, Division of Endocrinology, University of Rome "La Sapienza", Italy;(2) Department of Cardiology, II Faculty of Medicine, University of Rome "La Sapienza", Rome, Italy;(3) Department of Terapia Medica, University of Rome "La Sapienza", Italy;(4) Cardiac Catheterisation Unit, Casa di Cura Montevergine di Mercogliano (Av), Italy;(5) Department of Human Genetics and Metabolism, St. Bartholomew's Hospital, London, UK |
| Abstract: | Background Current evidence demonstrates that positive family history and several alterations in lipid metabolism are all important risk factors for coronary artery disease (CAD). All lipid abnormalities themselves have genetic determinants. Thus, objective of this study was to determine whether 6 genetic variants potentially related to altered lipid metabolism were associated with CAD and with lipid abnormalities in an Italian population. These genetic variables were: apolipoprotein E (Apo E), Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and the hepatic lipase (LIPC) genes. Furthermore, an 8 years prospective analysis of clinical cardiovascular events was related to the various genetic markers. |
