A review of screening mammography: The benefits and radiation risks put into perspective |
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| Institution: | 1. Sunnybrook Health Sciences Centre, Canada;2. University of Toronto, Canada;1. Nuclear Medicine Unit, Ente Ecclesiastico Ospedale Generale Regionale “F.Miulli”, Bari, Acquaviva delle Fonti, Italy;2. UOC Radiologia, Azienda Ospedaliera Regionale San Carlo, Potenza, Italy;3. Istituto di Clinica delle malattie infettive, Università Cattolica del Sacro Cuore, Roma, Italy;4. Dipartimento di Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Malattie infettive, Roma, Italy;5. Dipartimento di Diagnostica per immagini, Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Radiologia Diagnostica e Interventistica Generale, Radioterapia oncologica ed ematologia, Roma, Italy;1. Radiography Department, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P.O Box KB 143, Korle-Bu Campus, Accra, Ghana.;2. Department of Nuclear Safety and Security, School of Nuclear and Allied Sciences, University of Ghana, Atomic Campus, Accra, Ghana, Legon.;3. Medical Physics Department, School of Nuclear and Allied Sciences, University of Ghana, Atomic Campus, Accra, Ghana.;4. Radiation Protection Institute (RPI), Ghana Atomic Energy Commission, Accra, Ghana.;5. Radiological and Non-ionizing Radiation Directorate, Nuclear Regulatory Authority, Accra, Ghana. |
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| Abstract: | Introduction/BackgroundIn medical imaging a benefit to risk analysis is required when justifying or implementing diagnostic procedures. Screening mammography is no exception and in particular concerns around the use of radiation to help diagnose cancer must be addressed.MethodsThe Medline database and various established reports on breast screening and radiological protection were utilised to explore this review.Results/DiscussionThe benefit of screening is well argued; the ability to detect and treat breast cancer has led to a 91% 5-year survival rate and 497 deaths prevented from breast cancer amongst 100,000 screened women. Subsequently, screening guidelines by various countries recommend annual, biennial or triennial screening from ages somewhere between 40–74 years. Whilst the literature presents different perspectives on screening younger and older women, the current evidence of benefit for screening women <40 and ≥75 years is currently not strong. The radiation dose and associated risk delivered to each woman for a single examination is dependent upon age, breast density and breast thickness, however the average mean glandular dose is around 2.5–3 mGy, and this would result in 65 induced cancers and 8 deaths per 100,000 women over a screening lifetime from 40–74 years. This results in a ratio of lives saved to deaths from induced cancer of 62:1.ConclusionTherefore, compared to the potential mortality reduction achievable with screening mammography, the risk is small. |
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