CHEMOTHERAPY FOR SMALL CELL LUNG CANCER: INPUCTION AND REINDUCTION WITH VOCA |
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| Authors: | R. STUART-HARRIS D. RAGHAVAN R. H. FOX G. PERETZ C. CROMBIE N. TERIANA I. YOUNG P. BYE K. TIVER D. GREEN |
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| Affiliation: | Medical Oncologist, Ludwig Institute for Cancer Research, University of Sydne;Staff Specialist. Department of Clinical Oncology, Royal Prince Alfred Hospital, NSW;Medical Oncologist. Ludwig lnstitute for Cancer Research, University of Sydney;Staff Specialist, Department of Diagnostic Radiology, Royal Prince Alfred Hospital, NSW;Registrar, Department of Clinical Oncology, Royal Prince Alfred Hospital, NSW;Data Manager, Ludwig Institute for Cancer Research, University of Sydney;Staff Spedlalist Department of Thoracic Medicine, Royal Prince Alfred Hospital NSW;Staff Specialist, Department of Thoracic Medicine, Royal Prince Alfred Hospital, NSW;Staff Specialist, Department of Radiation Oncology, Westmead Hospital, NSW;Director, Department of Radiation Oncology, Royal Prince Alfred Hospital, NSW |
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| Abstract: | Abstract Sixty-five patients with small cell lung cancer were treated with VP16, vincristine, cyclophosphamide, and doxorubicin (VOCA) intravenously at three-week intervals. Patients with limited disease received four cycles with responders receiving radiation to the primary site and prophylactic cranial irradiation. Patients with extensive disease received chemotherapy only. Of 59 patients evaluable for chemotherapy response, eight (14%) achieved complete remission and 30 (51%) partial remission. Major side-effects included myelosuppression, alopecia, nausea, and vomiting. Reinduction with VOCA at relapse yielded objective or subjective response in four of seven patients. This regimen is active in small cell lung cancer and was well tolerated by patients. Reinduction of resDonse was Dossible in a small number of Datients retreated and mav provide useful palhation for those who relapse when treatment is discontinued. |
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| Keywords: | Chemotherapy radiotherapy small cell lung cancer. |
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