The relationship between hs-CRP and asthma control test in asthmatic patients |
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| Authors: | Hatice Kilic Aysegul Karalezli H Canan Hasanoglu Ozcan Erel Can Ates |
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| Institution: | 1. Ataturk Hospital Chest Department, Ankara, Turkey;2. Ataturk Hospital Biochemical Department, Ankara, Turkey;3. AUFM Biostatistics Department, Ankara, Turkey;1. National Health and Medical Research Council Centre for Research Excellence in Severe Asthma, Newcastle, Australia;2. The Priority Research Centre for Health Lungs, The University of Newcastle, Newcastle, Australia;3. School of Medicine and Public Health, The University of Newcastle, Newcastle, Australia;4. Department of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, China;5. Department of Respiratory and Sleep Medicine, John Hunter Hospital, Hunter Medical Research Institute, Newcastle, Australia;6. School of Nursing and Midwifery, The University of Newcastle, Newcastle, Australia;7. Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, Australia;1. Department of Research, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio;2. Division of Immunology, Allergy and Rheumatology, Department of Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio;3. Division of Allergy and Immunology, Cincinnati Children''s Hospital Medical Center, Cincinnati, Ohio;4. Division of Emergency Medicine, Cincinnati Children''s Hospital Medical Center, Cincinnati, Ohio;5. Division of Cellular and Molecular Immunology, Cincinnati Children''s Hospital Medical Center, Cincinnati, Ohio;6. Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio;1. School of Nutritional Science and Dietetics, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Pathology and Laboratory Medicine, Boston Medical Center, Boston, MA, USA;3. Tehran University of Medical Science, Tehran, Iran;4. Department of Medicine, Section of Endocrinology, Nutrition and Diabetes, Vitamin D, Skin and Bone, Research Laboratory, Boston University Medical Center, Boston, MA, USA;1. Department of Dermatopharmacology, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom;2. Department of Paediatric Allergy & Immunology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom |
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| Abstract: | BackgroundHigh sensitive C-reactive protein (hs-CRP) has been shown to be associated with asthma in recent studies. However, the relationship between hs-CRP and the control of asthma has not been clearly identified yet.ObjectiveTo investigate the association of hs-CRP with asthma control test (ACT), which reveals the degree of asthma control, and to compare hs-CRP in adults with mild and moderate asthma in chronic, stable asthmatic patients.MethodsThirty patients with physician-diagnosed asthma (11 mild, 19 moderate), and 30 healthy patients were enrolled in the study. In addition to medical history and physical examination, asthma was assessed according to GINA guideline. Respiratory function tests (RFT) and ACT were performed. The serum hs-CRP levels of all cases patients were measured.ResultsThe levels of hs-CRP in asthmatic patients were significantly higher than those in the control cases (p = 0.002). The serum hs-CRP levels in the moderate asthmatics were significantly higher than those in the mild asthmatic ones (p = 0.04). When asthmatic cases were divided into two groups according to ACTs; the levels of hs-CRP in the groups of ACT ≤ 20 (uncontrolled groups) were significantly higher than the groups of ACT ≥ 20 (controlled groups) (p = 0.02). The hs-CRP levels showed significant correlations with ACT (p = 0.00, r = ?0.91) and asthma severity (p = 0.04, r = 038) in asthmatic patients.ConclusionIn conclusion it was shown that hs-CRP is related with asthma severity and ACT, and hs-CRP is a potential sensitive marker which reveals the severity and the control of asthma. |
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