人肠道病毒71型感染及其防治研究进展

手足口病主要发生在5岁以下婴幼儿,近年来在亚太地区多次暴发。其临床症状主要包括发热、食欲不振和疱疹等轻微症状,通常具有自限性;少数病例可进展,伴严重的中枢神经系统、呼吸系统和心血管系统并发症,甚至死亡。人肠道病毒71型(EV71)是手足口病最常见的病原体之一,且易导致重症病例,应引起高度重视。因此,本文阐述EV71感染机制与疫苗研发的最新进展,旨在为手足口病的预防与治疗提供一定启发和依据。

Progress on human enterovirus 71 infection and its prevention and treatment

Hand, foot and mouth disease (HFMD) mainly occurs among children under 5 years old, which broke out many times in the Asia-Pacific region recently. The clinical symptoms of HFMD mainly include fever, anorexia, herpes and other mild symptoms, usually self-limited but a few cases were complicated with serious central nervous system, respiratory, cardiovascular system complications, and even death. Human enterovirus 71 (EV71) is one of the most common pathogens of HFMD, and it is more likely to lead to severe cases, which should be paid great attention. This review summarizes the latest progress of EV71 infection mechanism and vaccine research and development, and to provide some inspiration and basis for the prevention and treatment of HFMD.