Adrenoceptors and Colocolonic Inhibitory Reflex |
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Authors: | S. Frances Hughes S. Mark Scott Marie-Anne Pilot Norman S. Williams |
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Affiliation: | Academic Department of Surgery, St Bartholomew's and The Royal London School of Medicine & Dentistry, Whitechapel, UK. |
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Abstract: | The colocolonic inhibitory reflex ischaracterized by inhibition of proximal colonic motilityinduced by distal colonic distension. The aim of thisstudy was to investigate the underlying neuralmechanisms of this reflex, in vivo , using an isolatedloop of canine colon. In five beagle dogs, motility wasrecorded from an exteriorized colonic loop via a serosalstrain gauge connected to a digital data logger and chart recorder. Inflation of a balloon inthe distal colon resulted in inhibition of motility inthe isolated loop. Inhibition of motor activitypersisted following injection of propranolol (100 g/kg intravenously), a -adrenoceptorantagonist, but was abolished following administrationof the 2-adrenoceptor antagonistyohimbine (200 g/kg intravenously). This studyconfirms that the colocolonic inhibitory reflex is mediatedvia the extrinsic nerves to the colon. As the reflex wasabolished by 2-, but not -adrenoceptor blockade, this indicates that thereflex pathway involves 2-adrenoceptors. |
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Keywords: | MOTILITY INHIBITORY REFLEX ADRENERGIC |
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