122例重症急性胰腺炎的疗效观察

探讨大量补液,同时应用低分子右旋糖酐和山莨菪碱(血液洗涤疗法)治疗重症急性胰腺炎的疗效。122例确诊急性胰腺炎的患者随机分为两组,治疗组(n=62)在中心静脉压监测下大量补液,同时应用低分子右旋糖酐500ml加入654-2 20mg静滴,每日一次。当中心静脉压接近或略高于正常时应用速尿(10-20)mg静推。对照组(n=60)常规使用奥曲肽(0.25mg/h)。治疗组平均腹痛缓解天数2.3天,平均住院天数12.5天,病死率0(0/62),7天治愈率67.74％(42/62);对照组平均腹痛缓解天数6.5天,平均住院天数34.7天,病死率11.7％(7/60)及7天的治愈率30％(18/60)。两组比较均有显著性差异。在常规治疗基础上,应用低分子右旋糖酐和山莨菪碱,能控制病情进展,缩短病程和住院天数,显著降低病死率,提高治愈率。

122 cases treatment study for severe acute pancreatitis

To evaluate the effection of mass fluid replace and intravenous int romission anisodamine and low molecular dextran in the treatment of severe acute pancreatitis(SAP). 122 SAP patients were rando nly divided into the treatment group(n = 62) receiving mass fluid replace and intravenous intromission anisodamine 20mg and low molecular dextran 500ml per day, and the control group (n = 60) receiving intravenous octreotide (0.25mg/h) as a routine treatme nt. Mean days of relief from abdominal pain, case - fatality rate, hospital stay, and cure rate were compared between the two groups, t - test and x2 - test of Stata Software were used in statistics. Mean days of relief from abdominal pain, case - fatality rate, hospital stay, cure rate, between the beatment group and the control group were 2.3days vs 6.5days, 0 vs 11.7% ,12.5days vs 34.7days, 67.74% vs 30%. Mass fluid replace and intravenous intromission anisodamine and low molecular dextran on the basis of routine treatment helps control and reduce complications, shorten the course of disease and hsopital stay, reduce case - fatslity rate, increase cure rate.