婴儿早期骨代谢生化指标与声波速度值和出生后年龄间的关系 |
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引用本文: | 廖祥鹏 张立 卫雅蓉 张伟利 何稼敏 孙建华 黄萍. 婴儿早期骨代谢生化指标与声波速度值和出生后年龄间的关系[J]. 中国骨质疏松杂志, 2009, 15(7): 496-500. DOI: 10.3969/j.issn.1006-7108.2009.07.005 |
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作者姓名: | 廖祥鹏 张立 卫雅蓉 张伟利 何稼敏 孙建华 黄萍 |
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作者单位: | 1. 214002,南京医科大学附属无锡妇幼保健院;上海交通大学医学院附属新华医院上海市儿科医学研究所 2. 南京医科大学附属无锡妇幼保健院,214002 3. 上海交通大学医学院附属新华医院上海市儿科医学研究所 4. 上海交通大学医学院附属上海市儿童医学中心 |
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摘 要: | 目的 探讨婴儿早期骨代谢生化指标与声波速度值和出生后年龄间的关系.方法 采用骨定量超声(QUS)仪对167例出生3月内的婴儿进行胫骨声波速度(SOS)测量.其中包括53例早产儿(胎龄:32.6±2.7周)和114例足月儿(胎龄:39.1±1.2周);同时在部分婴儿中测量血钙、磷、碱性磷酸酶(ALP)和骨碱性磷酸酶(BALP).结果 ①早产儿和足月儿的血钙、磷、ALP和BALP值之间均差异无显著性.②婴儿骨SOS值与ALP呈显著负相关(n=167,r=-0.139,P=0.036)、与BALP也显著负相关(n=32,r=-0.410,P=0.010);SOS值与血钙、血磷及血钙磷乘积无显著性相关.在早产儿中,ALP和BALP与日龄均显著相关,相关系数r分别为0.286(n=53,P=0.019)和0.946(n=7,P=0.001);在足月儿中未发现显著相关性.血磷与日龄呈显著负相关(n=24,r=-0.509,P=0.005).③ALP与BALP高度相关(n=32,r=0.958,P=0.001),BALP占ALP活力的47.3%.早产儿在出生时BALP和Ⅰ型胶原羧基端肽(IcTP)显著正相关(n=36,r=0.768,P=0.001).结论 定量超声技术测量SOS有助于我们评估婴儿早期骨状况;在此横向研究中我们发现骨SOS与骨代谢生化指标之间存在相关性,然而,二者间的纵向关系有待于进一步研究.
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关 键 词: | 婴儿 早产 超声检查 声波速度 骨碱性磷酸酶 |
Correlations among biochemical markers of bone turnover,bone speed of sound and postnatal age in early infancy |
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Abstract: | Objective To examine the correlations among biochemical markers of bone turnover,bone speed of sound and postnatal age in early infancy. Materials and methods: A quantitative ultrasound bone sonometer was used to measure the bone speed of sound (SOS) of the tibia in 167 infants within 3 months of birth, including 53 preterm infants (gestational age 32.6±2.7 weeks) and 114 full-term infants (gestational age 39.1±1.2 weeks). Serum calcium, phosphorus, bone alkaline phosphatase (ALP), bone alkaline phosphatase (BALP) were examined at the same time among some of them. Results: 1) There were no significant differences of serum calcium, phosphorus, ALP and BALP between preterm infants and full-term infants. 2) There were significantly inverse correlations between SOS and ALP (n=167,r=-0.139,P=0.036), as well as between SOS and BALP (n=32,r=-0.410,P=0.010) in infants, however, no such relationships between SOS and serum calcium,phosphorus, and calcium phosphorus product (serum calcium multiplied by serum phosphorus) were found. When infants were divided into two groups: in preterm infants there were significant correlations between ALP and postnatal day(n=53,r=0.286,P=0.019)and also between BALP and postnatal day(n=7,r=0.946,P=0.001); But in full-term infants, no such relationships were found. There were significantly inverse correlations between serum phosphorus and postnatal day (n=24,r=-0.509,P=0.005). 3) ALP was significantly correlated with BALP(n=32,r=0.958,P=0.001)and BALP accounted for 43.7% of total value of ALP. There was significantly correlation between BALP and carboxyterminal telopeptide type I collangon (IcTP) in preterm infants at birth (n=36,r=0.768,P=0.001). Conclusions: Measurement of SOS with QUS is able to help us to evaluate bone status during early infancy. While in this cross-sectional study we have found some correlations between bone SOS and biochemical indexes of bone turnover in China, the long-term relationships among them remain to be studied further. |
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Keywords: | Infant,premature Ultrasonoyraphy Speed of sound Bone-specific alkaline phosphate |
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