十二烷氮酮氟尿嘧啶凝胶治疗疣及银屑病150例

443例(男225例,女218例;年龄36±14a)皮肤病患者,其中150例(扁平疣52例、寻常疣55例、银屑病43例)外用含1.8％十二烷氮(艹卓)酮的1％氟尿嘧啶(5-FU)凝胶作为治疗组,148例外用1％5-FU凝胶及145例外用2.5％5-FU霜作为2个对照组。经双盲对照临床试验,结果表明含1.8％十二烷氮(艹卓)酮的1％5-FU凝胶的疗效明显优于2个对照组(P<0.01及P<0.005)。证明氮(艹卓)酮对5-FU确有渗透促进作用。

Therapy of warts and psoriasis with fluorouracil lauro-eapram gel in 150 patients

In this study, 443 patients(M225, F218, age 36+14a) with warts and psoriasis were divided into 3 groups by randomized and double-blind method. The first group (n=150, verruca planae 52, verruca vulgaris 55, psoriasis 43) were given 1% fluorouracil (5-FU) in 1.8% laurocaprarn gel topically, the second group (n=148) 1% 5-FU gel and the third group (n=145) 2.5% 5-FU cream. The latter 2 groups served as controls. Results showed that the first group revealed a much better therapeutic effect than that of the control groups (P<0.01). It demonstrates that the laurocaprarn docs promote the permeability of 5-FU.