喉癌人类组织相容性抗原Ⅰ缺失与癌组织中淋巴细胞浸润的研究 |
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关 键 词: | 喉癌 人类组织相容性抗原I缺失 淋巴细胞浸润 |
Research into the human leucocyte antigen I deletion and local lymphocytes infiltration in laryngeal carcinoma] |
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Authors: | Chunbo Niu Xinmei Liu Weiguo Zhou Ling Jing Baodong Du |
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Institution: | Department of Otorhinolaryngology Head & Neck Surgery, First Hospital Affiliated to Jilin University, Changchun 130021, China. niuchunbo@hotmail.com |
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Abstract: | OBJECTIVE: To detect the deletion of human leucotyte antigen (HLA) class I antigen expression in laryngeal carcinoma tissue and discuss the relationship between its expression and tumor infiltrating lymphocyte (TIL) cell infiltration or/and malignancy of tumor cell. METHODS: From Feb 2001 to May 2001 specific mouse antihuman HLA class I monoclonal antibody was combined to examined tissue, 64 samples of laryngeal carcinoma were detected by streptavidin-peroxidase (SP) method immunohistochemistry. RESULTS: All of 64 cases, 57 were positive HLA class I antigen and 7 were negative, the negative expression rate was 10.9% (7/64). CD3+ and CD8+ T cell infiltrated in HLA class I positive tumor mass were significantely more than those in negative tissue. the malignant degree elevated along with the declination of HLA class I antigen expression. By 3 years follow up, the mortalitywas not statistically significant in both HLA- group and HLA+ group (P > 0.05). CONCLUSION: There is deletion of HLA class I antigen in laryngeal tissue, which favours penetration of cytotoxic lymphoid cells into tumor mass; alteration in HLA class I expression may be used by cancer cells to avoid immune surveillance. |
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