| 解聚复肾宁对糖尿病大鼠肾脏的保护作用 |
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| 引用本文： | 陈益山,曹文富,焦颖华,肖柯. 解聚复肾宁对糖尿病大鼠肾脏的保护作用[J]. 中国老年学杂志, 2010, 30(1) |
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| 作者姓名： | 陈益山 曹文富 焦颖华 肖柯 |
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| 作者单位： | 重庆医科大学附属第一医院中西医结合科,重庆,400016 |
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| 摘 要： | 目的 观察中药复方解聚复肾宁(JJFSN)对糖尿病 (DM)大鼠肾脏的保护作用.方法 建立链脲佐菌素(STZ)诱导的DM大鼠模型,将成模大鼠随机分成4组:模型组、JJFSN组、厄贝沙坦组、JJFSN+厄贝沙坦组,并设正常对照组.各组大鼠采用相应的干预措施处理12 w.常规方法检测各组大鼠尿白蛋白排泄率(UAER)等指标,免疫组化法检测肾血管内皮生长因子(VEGF)和骨形成蛋白7(BMP-7)表达,Western印迹检测肾组织血小板衍化生长因子B(PDGF-B)的表达,透射电镜观察肾脏超微结构.结果 模型组大鼠除肾BMP-7表达显著减少外,其余指标均显著增高,肾脏超微结构改变明显;JJFSN组、厄贝沙坦组和JJFSN+厄贝沙坦组除肾BMP-7显著高于模型组(P＜0.05)外,其余指标均显著低于模型组(P＜0.05),肾脏超微结构改变明显改善;JJFSN+厄贝沙坦组各项指标改善明显优于模型组、JJFSN组和厄贝沙坦组(P＜0.05),但未达到正常对照组水平.结论 JJFSN对DM大鼠肾脏有明显保护作用.
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| 关 键 词： | 解聚复肾宁 糖尿病 |
Protective effect of Jiejufushenning on diabetic nephropathy in rats |
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| CHEN Yi-Shan,CAO Wen-Fu,JIAO Ying-Hua,et al.. Protective effect of Jiejufushenning on diabetic nephropathy in rats[J]. Chinese Journal of Gerontology, 2010, 30(1) |
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| Authors: | CHEN Yi-Shan CAO Wen-Fu JIAO Ying-Hua et al. |
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| Affiliation: | CHEN Yi-Shan,CAO Wen-Fu,JIAO Ying-Hua,et al.Department of Traditional Chinese Medicine,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China |
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| Abstract: | Objective To investigate the effect of Jiejufushenning(JJFSN)on renal protection in diabetic nephropathy rats.Methods The diabetic SD rats induced by STZ were divided into 4 groups:model,JJFSN,irbesartan and JJFSN combined with irbesartan and control group.Rats in each group were respectively treated for 12 weeks by the appropriate intervention methods.The relative urinary albumin excretion rate(UAER),and other indicators were detected by routine analysis methods,and VEGF and BMP-7 in renal tissue were dete... |
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| Keywords: | Jiejufushenning Diabetes |
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