| 马桑内酯致痫大鼠大脑皮层,海马谷氨酸、门冬氨酸、甘氨酸及γ-氨基丁酸含量的测定 |
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| 引用本文： | 王群,龙洁,张在强,赵性泉. 马桑内酯致痫大鼠大脑皮层,海马谷氨酸、门冬氨酸、甘氨酸及γ-氨基丁酸含量的测定[J]. 脑与神经疾病杂志, 1999, 0(6) |
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| 作者姓名： | 王群 龙洁 张在强 赵性泉 |
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| 作者单位： | 北京天坛医院神经内科!100050 |
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| 摘 要： | 为了探讨氨基酸类神经递质在癫痫发病中的作用，我们采用高效液相色谱仪（HPLC）结合紫外分光光度仪分析检测了马桑内脂（CL）致病大鼠大脑皮层、海马Glu、Asp、Gly、GABA的含量变化。结果显示：CL致痫组与正常对照组相比，Glu、Asp、Gly含量增加（P<0.01，P<0.05）；GABA含量减少，但差异无显著性（P＞0．05）。这些结果提示兴奋性和抑制性氨基酸在癫痫发病中具有重要作用，可能参与了惊厥的发生、发展和惊厥后神经元损伤。
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| 关 键 词： | 癫痫 谷氨酸 门冬氨酸 甘氨酸 γ-氨基丁酸 |
Alterations of glutamate (Glu), aspartate (Asp), glycine (Gly) and gamma aminobutyric acid (GABA) contents in cerebral cortex and hippocampus of seizure rats induced by coriaria lactone (GL) |
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| Wang Qun, Lgug Jie, Zhang Zaiqiang,et al.. Alterations of glutamate (Glu), aspartate (Asp), glycine (Gly) and gamma aminobutyric acid (GABA) contents in cerebral cortex and hippocampus of seizure rats induced by coriaria lactone (GL)[J]. Journal of Brain and Nervous Diseases, 1999, 0(6) |
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| Authors: | Wang Qun Lgug Jie Zhang Zaiqiang et al. |
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| Affiliation: | Wang Qun, Lgug Jie, Zhang Zaiqiang, et al. |
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| Abstract: | objective: The experiment was designed to elucidate the role of excitatory and inhibitoryamino acids (EAAs, IAAs) in the pathogenesis of epilepsy. Methods: We determined the contents of Glu,Asp.Gly and GABA in cerebral cortex and hippocampus in rats 60 minutes post-seizure induced by CL byhigh performance liquid chromatography with fluorimetric detection of OPT derivatives. ` Results: Theresults showed that the levels of Glu' Asp and Gly at two regions in seizwe rats induced by CL wereincreased (P<0. 01, P<0. 05 ), and there was no difference in GABA content between convulsive andnormal control groups (P > 0.05). Conclusion: These findings indicate that EAAs and IAAs areprobabaly involved in the pathophysiology of epileptogenesis, neuronal damage and death after seizure. |
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| Keywords: | Seizure Glu Asp Gly GABA |
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