安胎汤联合西药治疗早期先兆流产临床研究

目的：观察安胎汤联合西药治疗早期先兆流产的临床疗效。方法：采用随机数字表法将164例早期先兆流产患者分为对照组、试验组各82例。对照组予以黄体酮注射液、地屈孕酮治疗，试验组在对照组基础上加用安胎汤治疗，2组均治疗2周。比较2组治疗前后基础体温、激素水平、中医证候积分，评估2组临床疗效及妊娠结局。结果：治疗后，试验组总有效率84.15%，高于对照组70.73%(P<0.05)。治疗后，2组血清孕酮(P)、雌二醇(E₂)、β-人绒毛膜促性腺激素(β-HCG)及基础体温水平较治疗前升高(P<0.05)，中医证候积分降低(P<0.05)；试验组治疗后P、E₂、β-HCG及基础体温水平高于对照组(P<0.05)，中医证候积分低于对照组(P<0.05)。试验组流产率低于对照组(P<0.05)，足月产率高于对照组(P<0.05)。2组早产率比较，差异无统计学意义(P>0.05)。结论：安胎汤联合西药治疗早期先兆流产疗效确切，能够调节患者激素水平，改善妊娠结局，提高保胎效果。

Clinical Study on Antai Decoction Combined with Western Medicine for EarlyThreatened Abortion

Abstract： Objective： To observe the clinical effect of the therapy of Antai Decoction combined withwestern medicine on early threatened abortion. Methods： A total of 164 patients with early threatenedabortion were divided into the control group and the trial group by random number table method ， with82 patients in each group. The control group was treated with Progesterone Injection and Dydrogesterone，and the trial group was treated with Antai Decoction based on the treatment of the control group. Bothgroups were treated for 2 weeks. The basal body temperature， hormone levels and traditional Chinesemedicine (TCM) syndrome scores in the two groups were compared before and after treatment， and theclinical effects and pregnancy outcome were evaluated in the two groups. Results： After treatment， the total effective rate was 84.15% in the trial group，higher than that of 70.73% in the control group (P＜0.05).After treatment， the levels of serum progesterone (P)， estradiol (E2)， β-human chorionic gonadotropin(β-HCG) and basal body temperature in the two groups were increased when compared with those beforetreatment (P＜0.05)， and the TCM syndrome scores were decreased (P＜0.05)； after treatment， thelevels of P，E2，β-HCG and basal body temperature in the trial group were higher than those in the controlgroup (P＜0.05)，and the TCM syndrome scores were lower than those in the control group (P＜0.05). Theabortion rate in the trial group was lower than that in the control group (P＜0.05)， and the full-term birthrate was higher than that in the control group (P＜0.05). There was no significant difference in the pretermbirth rate between the two groups (P＞0.05). Conclusion： The therapy of Antai Decoction combined withwestern medicine has a significant therapeutic effect on early threatened abortion，which can regulate thehormone levels of patients，improve the pregnancy outcome and enhance the effect of fetal protection.