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1,2-Difunctionalized bicyclo[1.1.1]pentanes: Long–sought-after mimetics for ortho/meta-substituted arenes |
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| Authors: | Jin-Xin Zhao Yu-Xuan Chang Chi He Benjamin J Burke Michael R Collins Matthew Del Bel Jeff Elleraas Gary M Gallego T Patrick Montgomery James J Mousseau Sajiv K Nair Matthew A Perry Jillian E Spangler Julien C Vantourout Phil S Baran |
| Institution: | aDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037;bState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China;cOncology Medicinal Chemistry, Pfizer Worldwide Research, Development and Medical, San Diego, CA, 92121;dDiscovery Sciences, Medicine Design, Pfizer Worldwide Research, Development and Medical, Groton, CT, 06340 |
| Abstract: | |
| Keywords: | synthesis medicinal chemistry bioisosteres |