Somatostatin,glucagon, and insulin secretion from isolated perfused pancreas of new genetically obese hyperglycemic rats |
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Authors: | Yutaka Seino Susumu Seino Masaru Usami Kinsuke Tsuda Jiro Takemura Shigeo Nishi Hitoshi Ishida Hiroo Imura |
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Affiliation: | 1. Second Division, Department of Medicine, Kyoto University School of Medicine, Kyoto, Japan.;2. the Diabetes Center, Ikeda Clinic, Amagasaki, Japan. |
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Abstract: | Insulin, somatostatin, and glucagon release from the perfused pancreas was studied in the newly developed genetically obese hyperglycemic hyperinsulinemic (Wistar fatty) rat. Insulin and somatostatin levels rose significantly compared to those in lean littermate controls during arginine infusion. The glucagon increase, however, was significantly less when total amounts during arginine infusion were calculated. These results show that hypersecretion of insulin and somatostatin in vitro may suppress glucagon release in Wistar fatty rats. |
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Keywords: | Address reprint requests to Yutaka Sieno MD Second Division Department of Medicine Kyoto University Faculty of Medicine Shogoin Kawahara-cho Sakyo-ku Kyoto 606 Japan. |
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