流行性出血热患者的血清胆固醇值及其与脂质过氧化反应的关系

作者测定了60例流行性出血热(EHF)患者的血清总胆固醇(TC)和血清脂质过氧化物(LPO)降解产物丙二醛(MDA),并对两者的关系进行研究,发现EHF患者TC水平较正常低,在低血压休克期和少尿期降至最低值(P<0.05).血清TC及甘油三酯与MDA的变化呈正相关(P<0.01).MDA/TC比值在EHF整个病程中均明显高于正常(P<0.05-0.01),病情最重时期比值最高,与MDA变化基本一致.作者认为LPO损伤在EHF的发病机理中可能具有重要意义,MDA的升高主要是由疾病本身所决定,而受血脂影响较小,MDA/TC比值代表了每单位水平胆固醇中MDA的相应含量,与MDA值相比,能更好地反映在血脂条件一定的憎况下LPO的真实水平.

Determination of blood cholesterol in patients with EHF and its relation to lipid peroxidation

The values of Mood total cholesterol(TC)and malondialdchydc (MDA), the degradation product of lipkl peroxidation (LPO), and their relationship have been studied in 60 patients with epidemic hemorrhage fever (EHF). The results indicated that TC value was lower in EHF patients with the lowest in hypotcnsive and oliguric phase (P<0.05). The alteration of MDA was correlated with TC and irigjyccride (P<0.01). The ratio of MDA/TC significantly increased obviously in the whole course of EHF ( P<0.05-0.01), and was paralleled with the change of MDA in EHF. The authors considered that LPO may be involved in the pathogenesis of EHF; the high level of MDA was caused mainly by the disease itself but slightly by blood lipid value. The ratio of MDA/TC represents the relevant content of MDA in each unit of cholesterol and thus reflects better the real level of LPO under a given blood lipid level.