血清PSA和FPSA/PSA比值在前列腺癌诊断中的意义

目的探讨PSA、FPSA及FPSA/PSA比值这三项指标对前列腺癌早期诊断的意义。方法采用ELISA方法分别对正常对照组43例,BPH组45例,PC组50例进行PSA、FPSA的检测及FPSA/PSA比值的计算。结果三组的各项指标均存在差异,BPH组和PC组病例在血PSA水平各阶段所占比例及相应FPSA/PSA比值差异均有显著性。结论PSA的灵敏度较高,但特异性较低,当PSA水平在0~10μg/L时,PC难以与BPH区分,测定PSA、FPSA同时求出FPSA/PSA比值,可以提高PC的诊断率及PC和BPH的鉴别诊断率,同时FPSA/PSA比值的灵敏度、特异性均优于血PSA和FPSA的单测结果。

The significance of PSA and FPSA/PSA to diagnosis of prostate carcinoma

Objective To investigate the significance of PSA,FPSA and FPSA/PSA to diagnose prostate carcinoma of early stage.Methods PSA and FPSA were detected by ELISA in normal control group of 43 patients,BPH group of 45 patients and PC group of 50 patients respectively.The value of FPSA/PSA was calculated.Results The levels of three markers had significant difference among three groups.The percentage of patients shared in different level of PSA had significant difference between BPH group and PC group.The value of FPSA/PSA in BPH group was significantly different from that in PC group.Conclusion PSA had high sensitivity and low specificity on the diagnosis of prostate carcinoma.In the PSA level of 0~10 μg/L,it was difficult in differentiating PC from BPH.detecting the levels of PSA,FPSA and FPSA/PSA could improve the accurate rate of diagnosing PC and differentiating PC from BPH.FPSA/PSA had better sensitivity and specificity than PSA and FPSA.