Present status of agonistic and antagonistic analogs of LH-RH in the treatment of advanced prostate cancer |
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| Authors: | AV Schally AM Comaru-Schally D Gonzalez-Barcena |
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| Affiliation: | Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112. |
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| Abstract: | The methods for treatment of advanced prostate cancer, based on the agonistic analogs of LH-RH were reviewed. New therapeutic approaches utilizing antagonistic analogs of LH-RH such as SB-75 (Cetrorelix) have been described. Analogs of LH-RH chemically linked to various cytotoxic radicals are also being developed. Combinations of LH-RH agonists or antagonists with superactive somatostatin analogues such as Octastatin (RC-160) or with bombesin/GRP antagonists are being investigated in order to delay or prevent the relapse and improve the therapy for prostate cancer. |
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